Barnes J N, Williams A J, Tomson M J, Toseland P A, Goodwin F J
Br Med J (Clin Res Ed). 1985 Mar 9;290(6470):740-2. doi: 10.1136/bmj.290.6470.740.
The pharmacokinetics of a single oral dose of dihydrocodeine were studied in nine patients with chronic renal failure treated by haemodialysis and nine subjects with normal renal function. In the patients the mean peak plasma dihydrocodeine concentration occurred later and the area under the curve was greater than in the normal subjects. Furthermore, the drug was still detectable after 24 hours in all the patients but only three of the normal subjects. These data, together with those obtained from previously published clinical case reports, contradict the traditional view that the body's ability to cope with opioid drugs is not altered in renal failure.
在9例接受血液透析治疗的慢性肾衰竭患者和9例肾功能正常的受试者中，研究了单次口服二氢可待因的药代动力学。与正常受试者相比，患者的血浆二氢可待因平均峰值浓度出现较晚，曲线下面积更大。此外，所有患者在24小时后仍可检测到该药物，而正常受试者中只有3例能检测到。这些数据，连同先前发表的临床病例报告中获得的数据，与传统观点相矛盾，即肾衰竭时人体应对阿片类药物的能力不会改变。
