Moore A, Sear J, Baldwin D, Allen M, Hunniset A, Bullingham R, McQuay H
Clin Pharmacol Ther. 1984 May;35(5):641-5. doi: 10.1038/clpt.1984.88.
Plasma concentrations after intravenous morphine were measured by a specific radioimmunoassay method in patients undergoing renal transplantation and in control subjects. In both transplant patients and controls, plasma morphine fell in the first 10 min, but there was no significant further fall in the transplant patients until between 3 and 5 hr, when there was an abrupt reversion to the same elimination t1/2 as the controls. This coincided with recovery of renal function after the period of cold ischemia. In the transplant patients the AUC over 24 hr was higher and the plasma clearance was lower than in controls. The role of the kidney in morphine elimination is discussed.
采用特定放射免疫分析方法测定了肾移植患者和对照受试者静脉注射吗啡后的血浆浓度。在移植患者和对照者中，血浆吗啡在最初10分钟内均下降，但移植患者直到3至5小时之间才出现显著进一步下降，此时突然恢复到与对照者相同的消除半衰期。这与冷缺血期后肾功能的恢复相吻合。移植患者24小时的曲线下面积（AUC）高于对照者，血浆清除率低于对照者。文中讨论了肾脏在吗啡消除中的作用。
