骨龄成熟度与儿童肥胖的关系。

Association between bone age maturity and childhood adiposity.

机构信息

Unit of Epidemiological Research in Endocrinology and Nutrition, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.

Clinical Epidemiology Research Unit, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.

出版信息

Pediatr Obes. 2024 Dec;19(12):e13166. doi: 10.1111/ijpo.13166. Epub 2024 Aug 26.

DOI:10.1111/ijpo.13166

PMID:39187394

Abstract

BACKGROUND

Evidence shows that overweight and obesity are associated with advanced bone age (BA).

OBJECTIVE

To analyse the effect of adiposity on BA among Mexican children.

METHODS

This cross-sectional study included 902 children (5-18 years old). Anthropometric measurements, dual-energy X-ray absorptiometry (DXA) and automated hand X-ray-based BA measurements were obtained. BA curves of children stratified by sex and age were created based on nutritional status. We also calculated odds ratios for advanced BA associated with the body mass index (BMI), waist/height ratio and adiposity estimated using DXA (total and truncal fat mass).

RESULTS

Participants with overweight/obesity by BMI (SDS ≥1) advanced earlier in BA than did normal weight participants (6.0 vs. 12.0 years in boys and 6.0 vs. 10.3 in girls, p < 0.01); similarly, participants with a greater body fat percentage (SDS ≥1) exhibited earlier advanced BA (7.5 vs. 10.0 years in boys and 6.0 vs. 9.6 in girls, p < 0.01). Differences were also observed according to the waist/height ratio and truncal fat. Children with a BMI or DXA SDS ≥1 had greater odds of presenting an advanced BA of more than 1 year (OR 1.79-3.55, p < 0.05).

CONCLUSIONS

Increased adiposity in children, mainly in boys, is associated with advanced BA at earlier ages.

摘要

背景

有证据表明，超重和肥胖与骨龄提前（BA）有关。

目的

分析肥胖对墨西哥儿童 BA 的影响。

方法

本横断面研究纳入了 902 名（5-18 岁）儿童。测量了人体测量学指标、双能 X 射线吸收法（DXA）和自动手部 X 射线 BA 测量值。根据营养状况，为不同性别和年龄的儿童创建了 BA 曲线。我们还计算了与 BMI（SDS≥1）、腰围/身高比和 DXA 估计的体脂（总脂肪量和躯干脂肪量）相关的 BA 提前的比值比。

结果

与 BMI 正常的参与者相比（男孩为 6.0 岁对 12.0 岁，女孩为 6.0 岁对 10.3 岁，p<0.01），BMI（SDS≥1）超重/肥胖的参与者 BA 提前更早；同样，体脂百分比（SDS≥1）更高的参与者 BA 也提前更早（男孩为 7.5 岁对 10.0 岁，女孩为 6.0 岁对 9.6 岁，p<0.01）。根据腰围/身高比和躯干脂肪，也观察到了差异。BMI 或 DXA SDS≥1 的儿童出现 BA 提前超过 1 年的可能性更大（OR 1.79-3.55，p<0.05）。