Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Ciberonc, Universidad de Oviedo, Oviedo, Spain.
Observatorio Marino de Asturias, Departamento de Biología de Organismos y Sistemas, Universidad de Oviedo, Oviedo, Spain.
Sci Rep. 2024 Aug 26;14(1):19748. doi: 10.1038/s41598-024-70642-w.
The demersal fish orange roughy (Hoplostethus atlanticus) can live for up to 250 years, twenty times more than its congener silver roughy (Hoplostethus mediterraneus). Studies of Hoplostethus have focused mainly on its ecology and conservation due to its vulnerability to commercial fishing. In this work, we present the de novo genomes of orange and silver roughies and explore the genomic mechanisms that could contribute to such differential longevities. Using comparative genomics on a list of more than 400 genes, we identified gene candidates with differential residue changes in Hoplostethus that are related to genomic instability, disabled macroautophagy and intercellular communication. We hypothesized that these mechanisms could have been selected as adaptations to the deep environment and, as an epiphenomenon of these mechanisms, may have contributed to an extension of the lifespan of H. atlanticus.
底栖鱼类橙连鳍鲑（Hoplostethus atlanticus）的寿命可达 250 年，比同属的银鲛（Hoplostethus mediterraneus）长 20 倍。由于橙连鳍鲑易受商业捕捞的影响，因此对其生态和保护的研究主要集中在这方面。在这项工作中，我们提供了橙连鳍鲑和银鲛的从头基因组，并探讨了可能导致这种差异寿命的基因组机制。通过对 400 多个基因的列表进行比较基因组学分析，我们鉴定了橙连鳍鲑中与基因组不稳定性、巨自噬功能障碍和细胞间通讯相关的差异残基变化的候选基因。我们假设这些机制可能是对深海环境的适应选择，而作为这些机制的附带现象，可能有助于延长 H. atlanticus 的寿命。
