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Lower-dose post-transplant cyclophosphamide in haploidentical hematopoietic cell transplantation.

作者信息

Fuji Shigeo, Nakamae Hirohisa, Sugita Junichi, Najima Yuho, Konishi Tatsuya, Tanaka Takashi, Nakashima Yasuhiro, Nishimoto Mitsutaka, Okamura Hiroshi, Nakayama Kazutaka, Ito Ayumu, Yoshimitsu Makoto, Hino Masayuki, Fukuda Takahiro, Atsuta Yoshiko, Yakushijin Kimikazu

机构信息

Department of Hematology, Osaka International Cancer Institute, Osaka, Japan.

Department of Hematology, Osaka Metropolitan University Hospital, Osaka, Japan.

出版信息

Bone Marrow Transplant. 2024 Nov;59(11):1628-1630. doi: 10.1038/s41409-024-02405-0. Epub 2024 Aug 26.

DOI:10.1038/s41409-024-02405-0
PMID:39187600
Abstract
摘要

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Lower-dose post-transplant cyclophosphamide in haploidentical hematopoietic cell transplantation.单倍体造血细胞移植中较低剂量的移植后环磷酰胺
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2
Haploidentical Transplantation with Post-Transplant Cyclophosphamide versus Unrelated Donor Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.单倍体相合移植联合移植后环磷酰胺与无关供者造血干细胞移植的比较：系统评价和荟萃分析。
Biol Blood Marrow Transplant. 2019 Dec;25(12):2422-2430. doi: 10.1016/j.bbmt.2019.07.028. Epub 2019 Aug 3.
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Lower Weight-Based Mycophenolate Mofetil Dosing is Associated with Superior Outcomes after Haploidentical Hematopoietic Cell Transplant with Post-transplant Cyclophosphamide.基于体重的吗替麦考酚酯低剂量与环磷酰胺后haploidentical 造血细胞移植后的优越结果相关。
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Increased early mortality after fludarabine and melphalan conditioning with peripheral blood grafts in haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide.在单倍体造血细胞移植中，使用氟达拉滨和美法仑进行预处理并联合外周血移植物，同时应用移植后环磷酰胺，早期死亡率增加。
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Salvage Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplant With Posttransplant Cyclophosphamide for Graft Failure in a Patient With Chronic Active Epstein-Barr Virus Infection.采用移植后环磷酰胺挽救性人类白细胞抗原半相合造血细胞移植治疗慢性活动性EB病毒感染患者的移植物失败
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Post-transplant cyclophosphamide or cell selection in haploidentical allogeneic hematopoietic cell transplantation?移植后环磷酰胺或细胞选择在单倍体相合异基因造血细胞移植中？
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Failure to Prevent Severe Graft-Versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide in Chronic Granulomatous Disease.在慢性肉芽肿病中，采用移植后环磷酰胺的单倍体相合造血细胞移植未能预防严重移植物抗宿主病。
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引用本文的文献

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Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation.不匹配无关供者外周血干细胞移植后基于移植后环磷酰胺的移植物抗宿主病预防
J Clin Oncol. 2025 Jun 16:JCO2500856. doi: 10.1200/JCO-25-00856.
2
Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation with Different Non-T-Cell Depletion Protocols.采用不同非T细胞去除方案的单倍体造血干细胞移植后的免疫重建
MedComm (2020). 2025 May 19;6(6):e70206. doi: 10.1002/mco2.70206. eCollection 2025 Jun.
3
Impact of post-transplant cyclophosphamide with bendamustine on immune reconstitution in young patients undergoing T-cell replete haploidentical bone marrow transplantation: results from a phase Ia/Ib clinical trial.

本文引用的文献

1
Low- versus standard-dose post-transplant cyclophosphamide as GVHD prophylaxis for haploidentical transplantation.低剂量与标准剂量移植后环磷酰胺预防单倍体相合移植后移植物抗宿主病。
Br J Haematol. 2024 Mar;204(3):959-966. doi: 10.1111/bjh.19228. Epub 2023 Nov 30.
2
Post-Transplant Cyclophosphamide for the Prevention of Graft-vs.-Host Disease in Allogeneic Hematopoietic Cell Transplantation: A Guide to Management for the Advanced Practitioner.移植后环磷酰胺用于预防异基因造血细胞移植中的移植物抗宿主病：高级从业者管理指南
J Adv Pract Oncol. 2023 Sep;14(6):520-532. doi: 10.6004/jadpro.2023.14.6.5. Epub 2023 Sep 1.
3
移植后环磷酰胺联合苯达莫司汀对接受T细胞充足的单倍体相合骨髓移植的年轻患者免疫重建的影响：一项Ia/Ib期临床试验结果
Front Immunol. 2025 Apr 9;16:1568862. doi: 10.3389/fimmu.2025.1568862. eCollection 2025.
Combining post-transplant cyclophosphamide with antithymocyte globulin for graft-versus-host disease prophylaxis in hematological malignancies.
在血液系统恶性肿瘤中，将移植后环磷酰胺与抗胸腺细胞球蛋白联合用于移植物抗宿主病预防。
Blood Rev. 2023 Nov;62:101080. doi: 10.1016/j.blre.2023.101080. Epub 2023 Apr 11.
4
Reduced post-transplant cyclophosphamide doses in haploidentical hematopoietic cell transplantation for elderly patients with hematological malignancies.老年血液系统恶性肿瘤患者单倍体造血细胞移植中移植后环磷酰胺剂量的降低
Bone Marrow Transplant. 2023 Apr;58(4):386-392. doi: 10.1038/s41409-022-01908-y. Epub 2022 Dec 30.
5
The next horizon now that everyone has a donor: Precision allogeneic transplantation.现在每个人都有供者了：下一个前沿领域是精准异体移植。
Blood Rev. 2023 Nov;62:100990. doi: 10.1016/j.blre.2022.100990. Epub 2022 Jul 14.
6
How we perform haploidentical stem cell transplantation with posttransplant cyclophosphamide.如何进行亲缘单倍体干细胞移植并使用移植后环磷酰胺。
Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):513-521. doi: 10.1182/hematology.2019001323.