Sun Jingjing, Chen Panlong, Liu Changxin, Zhang Zefeng, Kang Lulu, Ren Gang, Gao Xiaoli, Cao Lan, Chai Xingyun
Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330004, PR China.
Modern Research Center for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, PR China.
Chem Biodivers. 2024 Nov;21(11):e202401641. doi: 10.1002/cbdv.202401641. Epub 2024 Oct 11.
As a part of systematic research, an ongoing phytochemical investigation of the sesquiterpenoid-containing fraction led to the isolation of five new sesquiterpenoids from the peeled stems of Syringa pinnatifolia, including two pairs of enantiomeric humulane-type (±)-alashanoids A and B (1 and 2) and one eremophilane-type alashanoid C (3). These structures were elucidated by the analysis of extensive spectroscopic data, including ESI-MS and 1D and 2D NMR, and the absolute configuration was determined by comparing its experimental and calculated electronic circular dichroism and calculated NMR. These isolates exhibited moderate in vitro cardioprotective effects against oxidative injuries in H9c2 cells.
作为系统研究的一部分，对含倍半萜类成分的馏分进行的一项正在进行的植物化学研究，从羽状叶丁香的去皮茎中分离出了5种新的倍半萜类化合物，包括两对对映体的葎草烷型（±）-阿拉善酮A和B（1和2）以及一种艾里莫芬烷型阿拉善酮C（3）。通过对包括电喷雾电离质谱（ESI-MS）以及一维和二维核磁共振（1D和2D NMR）在内的大量光谱数据进行分析，阐明了这些化合物的结构，并通过比较其实验和计算的电子圆二色性以及计算的核磁共振确定了其绝对构型。这些分离出的化合物在体外对H9c2细胞的氧化损伤表现出中等程度的心脏保护作用。
