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自膨式金属支架作为结肠癌梗阻患者手术桥梁对长期生存结局的影响:现状与未来展望

Impact of self-expanding metal stents on long-term survival outcomes as a bridge to surgery in patients with colon cancer obstruction: Current state and future prospects.

作者信息

Zhang Hao-Yu, Wang Zhen-Jun, Han Jia-Gang

机构信息

Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Department of General Surgery, Beijing Xuanwu Hospital, Capital Medical University, Beijing, China.

出版信息

Dig Endosc. 2024 Dec;36(12):1312-1327. doi: 10.1111/den.14905. Epub 2024 Aug 27.

Abstract

Since self-expanding metal stents (SEMS) were first introduced in acute colon cancer obstruction, the increased rate of primary anastomosis and improved quality of life following SEMS placement have been clearly shown. However, it was demonstrated that SEMS are associated with higher recurrence rates. Although several trials have shown that overall and disease-free survival in patients following SEMS placement is similar with patients undergoing emergency surgery, obstruction and a high incidence of recurrence imposed many concerns. The optimal time interval from SEMS to surgery is still a matter of debate. Some studies have recommended a time interval of ~2 weeks between SEMS insertion and elective surgery. A prolonged interval of time from SEMS insertion to elective surgery and the administration of neoadjuvant chemotherapy (NAC) has been proposed. SEMS-NAC might have advantages for improving the surgical and long-term survival outcomes of patients with acute colon cancer obstruction, which is an optional approach in the management of acute colon cancer obstruction.

摘要

自从自膨式金属支架(SEMS)首次应用于急性结肠癌梗阻以来,SEMS置入后一期吻合率的提高和生活质量的改善已得到明确证实。然而,研究表明SEMS与较高的复发率相关。尽管多项试验表明,SEMS置入后患者的总生存率和无病生存率与接受急诊手术的患者相似,但梗阻和高复发率引发了诸多担忧。从SEMS置入到手术的最佳时间间隔仍存在争议。一些研究建议在SEMS置入与择期手术之间间隔约2周。有人提出延长从SEMS置入到择期手术以及给予新辅助化疗(NAC)的时间间隔。SEMS-NAC可能在改善急性结肠癌梗阻患者的手术和长期生存结局方面具有优势,这是急性结肠癌梗阻治疗中的一种可选方法。

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