Stanley P J, Cole P J
Clin Exp Immunol. 1985 Jan;59(1):197-202.
The concentrations of total IgA, 11S IgA, total and free secretory piece (SP) were measured in the nasal secretions of 39 patients with recurrent upper and lower respiratory tract infections during an infection free period. In all of eight patients who had selective serum IgA deficiency (less than 0.05 g/l) IgA was also undetectable in their nasal secretions and the mean concentration of free SP was significantly raised. However, the mean concentrations of 11S IgA, SP and free SP in nasal secretions of patients with normal or low (greater than 0.05 g/l but below the normal range) serum IgA were not significantly different from those of 10 healthy normal subjects. In patients with detectable nasal secretory IgA, 11S IgA concentrations correlated significantly (r = 0.57; P less than 0.001) with concentrations of free SP. One patient with normal serum IgA was found to have a large excess of free SP and therefore may have had a relative defect in local IgA production.
在39例反复发生上、下呼吸道感染的患者处于无感染期时，检测其鼻分泌物中总IgA、11S IgA、总分泌片（SP）和游离分泌片的浓度。在所有8例选择性血清IgA缺乏（低于0.05g/l）的患者中，其鼻分泌物中也检测不到IgA，游离SP的平均浓度显著升高。然而，血清IgA正常或偏低（大于0.05g/l但低于正常范围）的患者鼻分泌物中11S IgA、SP和游离SP的平均浓度与10名健康正常受试者相比无显著差异。在可检测到鼻分泌性IgA的患者中，11S IgA浓度与游离SP浓度显著相关（r = 0.57；P小于0.001）。发现1例血清IgA正常的患者游离SP大量过剩，因此可能存在局部IgA产生的相对缺陷。
