Bohman S O, Tydén G, Wilczek H, Lundgren G, Jaremko G, Gunnarsson R, Ostman J, Groth C G
Diabetes. 1985 Mar;34(3):306-8. doi: 10.2337/diab.34.3.306.
Kidney graft biopsies were performed 2-3 yr after transplantation in eight type I (insulin-dependent) diabetic patients who had previously been subjected to kidney transplantation (six patients) or combined kidney and segmental pancreas transplantation (two patients). In five of the six patients that had undergone only kidney transplantation, light microscopic examination of the graft biopsy revealed changes compatible with diabetic nephropathy, and electron microscopic morphometry showed a thickening of the glomerular basement membrane (GBM). In the two patients who had been subjected to combined pancreas and kidney transplantation, the kidney graft biopsy showed no light microscopic changes suggestive of diabetic nephropathy, and electron microscopy showed no thickening of the GBM. Thus, it appears to be possible to prevent the recurrence of diabetic nephropathy in human kidney allografts by simultaneous pancreas transplantation.
对8例I型（胰岛素依赖型）糖尿病患者进行了肾移植活检，这些患者此前接受过肾移植（6例）或肾和节段性胰腺联合移植（2例），活检在移植后2 - 3年进行。在仅接受肾移植的6例患者中，有5例移植肾活检的光镜检查显示有与糖尿病肾病相符的改变，电镜形态计量学显示肾小球基底膜（GBM）增厚。在接受胰腺和肾联合移植的2例患者中，移植肾活检光镜检查未显示提示糖尿病肾病的改变，电镜检查显示GBM未增厚。因此，同时进行胰腺移植似乎有可能预防人同种异体肾移植中糖尿病肾病的复发。
