Hein Matthieu, Wacquier Benjamin, Conenna Matteo, Lanquart Jean-Pol, Point Camille
Hôpital Universitaire de Bruxelles, Service de Psychiatrie et Laboratoire du Sommeil, Université Libre de Bruxelles, ULB, 1070 Brussels, Belgium.
Laboratoire de Psychologie Médicale et Addictologie (ULB312), Université Libre de Bruxelles, ULB, 1020 Brussels, Belgium.
Clocks Sleep. 2024 Jul 26;6(3):389-401. doi: 10.3390/clockssleep6030026.
Given the limitations of available studies, the objective of this study was to explore the role played by current and remitted major depression in the occurrence of comorbid insomnia disorder for apneic patients. Data from 1488 apneic patients were extracted from the medical reports of polysomnographic recordings available in the database of the Sleep Laboratory. The presence of comorbid insomnia disorder in these apneic patients was defined based on the diagnostic criteria of the American Academy of Sleep Medicine Work Group. The risk of comorbid insomnia disorder associated with current or remitted major depression in apneic patients was investigated using multivariate logistic regression models. After adjustment for the main confounding factors, multivariate logistic regression analyses revealed that remitted and current major depression were significantly associated with the occurrence of comorbid insomnia disorder in apneic patients. The findings of this study seem to indicate that comorbid insomnia disorder could be a residual symptom and a marker of major depression in apneic patients, which justifies the establishment of an adequate treatment for major depressive episodes and their potential residual symptoms to allow the better management of comorbid insomnia disorder and the better prevention of its potential negative consequences in this particular subpopulation.
鉴于现有研究的局限性，本研究的目的是探讨当前和缓解期的重度抑郁症在呼吸暂停患者共病失眠障碍发生中所起的作用。从睡眠实验室数据库中可用的多导睡眠图记录的医学报告中提取了1488名呼吸暂停患者的数据。这些呼吸暂停患者中共病失眠障碍的存在是根据美国睡眠医学学会工作组的诊断标准来定义的。使用多变量逻辑回归模型研究了呼吸暂停患者中与当前或缓解期重度抑郁症相关的共病失眠障碍风险。在对主要混杂因素进行调整后，多变量逻辑回归分析显示，缓解期和当前的重度抑郁症与呼吸暂停患者共病失眠障碍的发生显著相关。本研究的结果似乎表明，共病失眠障碍可能是呼吸暂停患者重度抑郁症的残留症状和标志物，这证明有必要针对重度抑郁发作及其潜在的残留症状建立适当的治疗方法，以便更好地管理共病失眠障碍，并更好地预防其在这一特定亚人群中的潜在负面后果。
