Dini Gianluca, Beccasio Alfredo, Della Lena Francesco, Verrotti Alberto, Cagini Carlo
Department of Pediatrics, University of Perugia, 06129 Perugia, Italy.
Department of Medicine and Surgery, Section of Ophthalmology, University of Perugia, S. Maria Della Misericordia Hospital, 06129 Perugia, Italy.
Pediatr Rep. 2024 Jul 24;16(3):594-601. doi: 10.3390/pediatric16030050.
Fluorescein angiography (FA) has been a pivotal tool for studying the pathophysiology of retinopathy of prematurity (ROP) in vivo. We examined the course of ROP using FA to assess the predictive value of angiographic features.
This is an observational retrospective cohort study of eyes screened for ROP with a binocular indirect ophthalmoscope and FA. RetCam fundus imaging and video digital fluorescein angiography were performed in the neonatal intensive care unit of Santa Maria Hospital of Perugia. The masked grading of the FA images was retrospectively conducted by two ROP expert ophthalmologists.
A total of 80 eyes of 40 patients were included for this study. Among the angiographic features evaluated, leakage, shunts, and tangles were predictive of the development of treatment-requiring ROP ( < 0.05).
FA can add to our understanding of the evolution of vascular abnormalities in the course of ROP and can help predict which eyes will go on to treatment.
荧光素血管造影（FA）一直是体内研究早产儿视网膜病变（ROP）病理生理学的关键工具。我们使用FA检查ROP的病程，以评估血管造影特征的预测价值。
这是一项对使用双目间接检眼镜和FA筛查ROP的眼睛进行的观察性回顾性队列研究。在佩鲁贾圣玛丽亚医院的新生儿重症监护病房进行RetCam眼底成像和视频数字荧光素血管造影。由两名ROP专家眼科医生对FA图像进行盲法分级。
本研究共纳入40例患者的80只眼。在评估的血管造影特征中，渗漏、分流和缠结可预测需要治疗的ROP的发生（<0.05）。
FA有助于我们了解ROP病程中血管异常的演变，并有助于预测哪些眼睛将需要治疗。
