李斯特菌易感和抗性小鼠品系中非特异性细胞毒性细胞的激活。
Activation of non-specific cytotoxic cells in Listeria-susceptible and -resistant mouse strains.
作者信息
Wood P, Cheers C
出版信息
Immunology. 1985 Jan;54(1):113-9.
Abstract
An increase in macrophage tumouricidal activity in the spleen was demonstrated following intravenous infection of genetically resistant C57BL/10 mice with Listeria monocytogenes, but not after infection of BALB/c mice. However, tumouricidal macrophages appeared in the peritoneal cavity of both strains after infection, while NK cell activity was generally higher in BALB/c mice. The activation of tumouricidal macrophages and NK cells in the C57BL/B10 mice was T independent and, at least in the peritoneal cavity, radioresistant (600 rads). The relevance of these results to the genetic control of resistance to Listeria is discussed.
摘要
将单核细胞增多性李斯特菌静脉注射给具有遗传抗性的C57BL/10小鼠后，其脾脏中的巨噬细胞杀肿瘤活性增强，但BALB/c小鼠感染后则未出现这种情况。然而，感染后两种品系小鼠的腹腔中均出现了杀肿瘤巨噬细胞，而BALB/c小鼠的自然杀伤（NK）细胞活性通常更高。C57BL/B10小鼠中杀肿瘤巨噬细胞和NK细胞的激活不依赖T细胞，并且至少在腹腔中具有放射抗性（600拉德）。文中讨论了这些结果与对李斯特菌抗性的遗传控制的相关性。
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