使用借氢法通过铜催化芴与伯醇和仲醇进行C(sp)-H烷基化反应。
Copper-catalyzed C(sp)-H alkylation of fluorene with primary and secondary alcohols using a borrowing hydrogen method.
作者信息
Saha Ratnakar, Maharana Suraj Kumar, Jana Narayan Ch, Bagh Bidraha
机构信息
School of Chemical Sciences, National Institute of Science Education and Research (NISER), An OCC of Homi Bhabha National Institute, Bhubaneswar, Jatni, Khurda, Odisha, 752050, India.
出版信息
Chem Commun (Camb). 2024 Sep 12;60(74):10144-10147. doi: 10.1039/d4cc03310h.
Despite the limited success of copper-catalyzed alkylations, (NNS)CuCl proved to be an effective catalyst for the sp C-H alkylation of fluorene with alcohols. Various primary alcohols and challenging secondary alcohols were successfully used. The practical applicability of the method was effectively tested with several post-functionalization reactions. This copper-catalyzed alkylation of fluorene involved a borrowing hydrogen mechanism.
尽管铜催化的烷基化反应成效有限，但（NNS）CuCl被证明是芴与醇进行sp C-H烷基化反应的有效催化剂。各种伯醇和具有挑战性的仲醇都成功得到了应用。该方法的实际适用性通过几个后官能团化反应得到了有效测试。这种铜催化的芴烷基化反应涉及借氢机理。
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