Göttlinger H G, Rieber P, Gokel J M, Lohe K J, Riethmüller G
Int J Cancer. 1985 Feb 15;35(2):199-205. doi: 10.1002/ijc.2910350210.
Frozen sections of 52 breast carcinomas were examined for the presence and nature of a leukocytic infiltrate. The number of "common leukocyte (T200-) antigen"-bearing cells was remarkably high in the stromal compartment of the carcinomas, whereas the tumor foci themselves were usually infiltrated only sparsely. Approximately 80% of these T200+ stromal cells carried the myelomonocyte lineage-associated antigens M-M522 and 63D3 and exhibited "non-specific esterase" activity. More than 2/3 of the stromal monocytic cells expressed the T4 antigen as verified by monoclonal antibodies (MAbs) directed against different T4-associated epitopes. A T-cell analysis showed that T4+ cells clearly outweighed the total number of T cells as defined by anti-T3 and anti-TII antibodies. In addition, a correlation became apparent between the HLA-DR phenotype and the T lymphocyte content of tumor cell areas in the sense that densely infiltrated tumor areas were invariably HLA-DR+.
对52例乳腺癌的冰冻切片进行检查，以确定白细胞浸润的存在和性质。在癌组织的间质部分，带有“普通白细胞（T200 -）抗原”的细胞数量显著高于肿瘤灶本身，而肿瘤灶本身通常仅有稀疏浸润。这些T200 +间质细胞中约80%携带与髓单核细胞系相关的抗原M - M522和63D3，并表现出“非特异性酯酶”活性。经针对不同T4相关表位的单克隆抗体（MAb）验证，超过2/3的间质单核细胞表达T4抗原。T细胞分析表明，T4 +细胞明显超过由抗T3和抗T11抗体定义的T细胞总数。此外，在肿瘤细胞区域的HLA - DR表型与T淋巴细胞含量之间出现了一种相关性，即浸润密集的肿瘤区域总是HLA - DR +。
