van't Riet A, Stam H C, Mak A C, van Slooten F H
Int J Radiat Oncol Biol Phys. 1985 Mar;11(3):621-5. doi: 10.1016/0360-3016(85)90198-1.
The influence of taking into account the lung density in the calculation of the dose distributions was examined for a group of 23 patients with bronchus carcinoma. Anatomical information and electron densities were available by means of CT scans. All calculations were made for cobalt-60 gamma rays using a patient specific multiple field irradiation technique. The effect of lung tissues for the dose distributions was calculated using a generalization of Batho's method. All patients entered into this study were planned to receive a minimum tumor dose of 60 Gy, calculated without correction for lung density. The actual dose in each patient was recalculated with lung correction. In the group of patients the corrected minimum tumor dose varied between 63 Gy and 77 Gy (105-128%). The calculated homogeneity of the dose in the target area and the dose to surrounding normal tissues are also affected by lung correction. For different radiation techniques and different methods of dose specification, the interrelation between corrected and uncorrected dose is presented in tables. The impact of lung correction on the uncorrected dose schedules that are commonly used in the treatment of patients with lung cancer is discussed.
对一组23例支气管癌患者，研究了在剂量分布计算中考虑肺密度的影响。通过CT扫描可获得解剖学信息和电子密度。使用患者特异性多野照射技术对钴-60γ射线进行所有计算。采用Batho方法的推广形式计算肺组织对剂量分布的影响。本研究纳入的所有患者计划接受的最小肿瘤剂量为60 Gy，该剂量计算时未对肺密度进行校正。对每位患者的实际剂量进行了肺校正重新计算。在该组患者中，校正后的最小肿瘤剂量在63 Gy至77 Gy之间变化（105%-128%）。肺校正也会影响靶区剂量计算的均匀性以及周围正常组织的剂量。对于不同的放射技术和不同的剂量规范方法，校正剂量与未校正剂量之间的相互关系列于表格中。讨论了肺校正对肺癌患者治疗中常用的未校正剂量方案的影响。
