Wang Huabin, Xu Lianhua, Liu Xiongwei, Shi Yang, Yao Zhen, Zhou Ying, Huang Qiang
College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, P. R. China.
School of Pharmacy, Zunyi Medical University, Zunyi 563006, P. R. China.
Org Biomol Chem. 2024 Sep 18;22(36):7518-7523. doi: 10.1039/d4ob01244e.
A facile and efficient protocol for P(O)-O bond formation was discovered through NaIO/air-initiated phosphorylation of alcohols with H-phosphine oxides in water. This reaction showed good functional group tolerance and a broad substrate scope, providing an alternative method for constructing P(O)-O bonds. Mechanistic studies suggested that a phosphoryl radical-involving process from H-phosphine oxides facilitated the phosphorylation of alcohols under air.
通过在水中用氢膦氧化物对醇进行NaIO/空气引发的磷酸化反应，发现了一种简便高效的形成P（O）-O键的方法。该反应具有良好的官能团耐受性和广泛的底物范围，为构建P（O）-O键提供了一种替代方法。机理研究表明，氢膦氧化物中涉及磷酰基自由基的过程促进了空气中醇的磷酸化反应。
