• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

作为抗癌药物的一些 3-取代-4-氧代-2-(1H)-噻唑烷-2-硫酮衍生物的细胞毒性筛选。

cytotoxicity screening of some 3-substituted-4-oxo-imidazolidin-2-(1H)-thione derivatives as anticancer drug.

机构信息

Department of Chemistry (The Division of Organic Chemistry), Faculty of Science, Port Said University, Port Said, Egypt.

Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt.

出版信息

Future Med Chem. 2024;16(14):1379-1393. doi: 10.1080/17568919.2024.2350925. Epub 2024 May 24.

DOI:10.1080/17568919.2024.2350925
PMID:39190474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11352705/
Abstract

This study aimed to investigate the antitumor activity of new series of 2-thiohydanotin derivatives ( and ) against two cancer cell lines. A new series of 2-thioxoimidazolidine derivatives () were synthesized and investigated for its structure through spectral analysis and also tested against (HepG-2) and (HCT-116) cell line. Among the synthesized compounds, compound halted liver cancer cells at the G0/G1 phase and triggered apoptosis of liver cancer. Contrarily, compound caused colon cancer cells to be arrested at the S phase and trigger apoptosis. Also, they had a good inhibitory effect on (Nrf2). Both compounds had attractive lead molecules for the creation of colon and liver cancer medications.

摘要

本研究旨在探讨一系列新型 2-硫代海因衍生物（和）对两种癌细胞系的抗肿瘤活性。合成了一系列新的 2-硫代恶唑烷衍生物（），通过光谱分析对其结构进行了研究，并对（HepG-2）和（HCT-116）细胞系进行了测试。在所合成的化合物中，化合物使肝癌细胞停滞在 G0/G1 期，并引发肝癌细胞凋亡。相反，化合物使结肠癌细胞停滞在 S 期并引发细胞凋亡。此外，它们对（Nrf2）有很好的抑制作用。这两种化合物都是用于开发结肠癌和肝癌药物的有吸引力的先导分子。

相似文献

1
cytotoxicity screening of some 3-substituted-4-oxo-imidazolidin-2-(1H)-thione derivatives as anticancer drug.作为抗癌药物的一些 3-取代-4-氧代-2-(1H)-噻唑烷-2-硫酮衍生物的细胞毒性筛选。
Future Med Chem. 2024;16(14):1379-1393. doi: 10.1080/17568919.2024.2350925. Epub 2024 May 24.
2
5-Aryl-1-Arylideneamino-1-Imidazole-2(3)-Thiones: Synthesis and In Vitro Anticancer Evaluation.5-芳基-1-芳亚氨基-1-咪唑-2(3)-硫酮：合成与体外抗癌活性评价。
Molecules. 2021 Mar 18;26(6):1706. doi: 10.3390/molecules26061706.
3
Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene.新型基于 4H-苯并[h]色烯的抗癌杂环衍生物的抗增殖作用、细胞周期阻滞和凋亡诱导
Bioorg Chem. 2019 Jun;87:560-571. doi: 10.1016/j.bioorg.2019.03.059. Epub 2019 Mar 22.
4
Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators.新型4-羟基-噻唑烷-2-硫酮衍生物作为肿瘤细胞特异性丙酮酸激酶M2激活剂的发现及其构效关系
Eur J Med Chem. 2018 Jan 1;143:48-65. doi: 10.1016/j.ejmech.2017.11.023. Epub 2017 Nov 10.
5
Biological Activity, Apoptotic Induction and Cell Cycle Arrest of New Hydrazonoyl Halides Derivatives.新型酰腙卤代物的生物活性、诱导细胞凋亡和细胞周期阻滞。
Anticancer Agents Med Chem. 2019;19(9):1141-1149. doi: 10.2174/1871520619666190306123658.
6
1,3,4-oxadiazole-2-thione Derivatives; Novel Approach for Anticancer and Tubulin Polymerization Inhibitory Activities.1,3,4-恶二唑-2-硫酮衍生物；抗癌及微管蛋白聚合抑制活性的新方法
Anticancer Agents Med Chem. 2015;16(2):269-77. doi: 10.2174/1871520615666150907093855.
7
Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents.合成并评价硫代葡萄糖苷类似物作为潜在的抗肿瘤药物。
Eur J Med Chem. 2013 Jun;64:529-39. doi: 10.1016/j.ejmech.2013.03.045. Epub 2013 Apr 6.
8
New thiazole-2(3H)-thiones containing 4-(3,4,5-trimethoxyphenyl) moiety as anticancer agents.含有 4-(3,4,5-三甲氧基苯基)部分的新型噻唑-2(3H)-硫酮类化合物作为抗癌剂。
Eur J Med Chem. 2020 Jan 1;185:111784. doi: 10.1016/j.ejmech.2019.111784. Epub 2019 Oct 15.
9
Design and Synthesis of New CDK2 Inhibitors Containing Thiazolone and Thiazolthione Scafold with Apoptotic Activity.新型含噻唑啉酮和噻唑烷酮结构骨架的 CDK2 抑制剂的设计与合成及其诱导细胞凋亡活性。
Chem Pharm Bull (Tokyo). 2021;69(1):106-117. doi: 10.1248/cpb.c20-00714.
10
Design, synthesis, single-crystal and preliminary antitumor activity of novel arenesulfonylimidazolidin-2-ones.新型芳基磺酰基咪唑烷-2-酮的设计、合成、单晶及初步抗肿瘤活性。
Bioorg Med Chem Lett. 2012 Mar 1;22(5):2008-14. doi: 10.1016/j.bmcl.2012.01.036. Epub 2012 Jan 21.

引用本文的文献

1
anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety.含 2-硫代海因杂环的肉桂酸衍生物的抗乳腺癌研究。
Future Med Chem. 2024 Aug 17;16(16):1665-1684. doi: 10.1080/17568919.2024.2366694. Epub 2024 Jul 1.

本文引用的文献

1
Design, Synthesis, Cytotoxic Screening and Molecular Docking Studies of Novel Hybrid Thiosemicarbazone Derivatives as Anticancer Agents.新型噻唑烷酮衍生物的设计、合成、细胞毒性筛选及分子对接研究作为抗癌剂。
Chem Biodivers. 2021 Dec;18(12):e2100580. doi: 10.1002/cbdv.202100580. Epub 2021 Nov 23.
2
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
3
Organocatalytic diastereoselective [3+2] cyclization of MBH carbonates with dinucleophiles: synthesis of bicyclic imidazoline derivatives that inhibit MDM2-p53 interaction.有机催化 MBH 碳酸酯与二亲核试剂的立体选择性[3+2]环化反应：抑制 MDM2-p53 相互作用的双环咪唑啉衍生物的合成。
Chem Commun (Camb). 2019 Sep 19;55(76):11374-11377. doi: 10.1039/c9cc05916d.
4
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
5
Imidazoles as potential anticancer agents.咪唑类作为潜在的抗癌药物。
Medchemcomm. 2017 Apr 13;8(9):1742-1773. doi: 10.1039/c7md00067g. eCollection 2017 Sep 1.
6
Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line.设计、合成和筛选 1,2,4-三嗪酮衍生物作为潜在的抗肿瘤药物，对 MCF-7 乳腺癌细胞系具有诱导细胞凋亡活性。
Eur J Med Chem. 2018 Aug 5;156:563-579. doi: 10.1016/j.ejmech.2018.07.003. Epub 2018 Jul 7.
7
Design, synthesis and evaluation of anticancer activity of novel 2-thioxoimidazolidin-4-one derivatives bearing pyrazole, triazole and benzoxazole moieties.含吡唑、三唑和苯并恶唑基团的新型2-硫代咪唑啉-4-酮衍生物的抗癌活性设计、合成与评价
Chem Cent J. 2018 May 9;12(1):51. doi: 10.1186/s13065-018-0418-1.
8
Identification of N-arylsulfonylpyrimidones as anticancer agents.鉴定 N-芳基磺酰基嘧啶酮类化合物为抗癌剂。
Arch Pharm Res. 2018 Mar;41(3):251-258. doi: 10.1007/s12272-018-1003-9. Epub 2018 Jan 13.
9
Antiproliferative and Apoptosis Inducing Effect of Bulb Extract on Breast, Cervical, and Liver Cancer Cells.鳞茎提取物对乳腺癌、子宫颈癌和肝癌细胞的抗增殖及诱导凋亡作用。
Front Pharmacol. 2017 Jan 31;8:5. doi: 10.3389/fphar.2017.00005. eCollection 2017.
10
An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy.Nrf2-ARE信号通路的化学抑制剂概述及其在癌症治疗中的潜在应用。
Free Radic Biol Med. 2016 Oct;99:544-556. doi: 10.1016/j.freeradbiomed.2016.09.010. Epub 2016 Sep 12.