具有优异综合性能的近红外二区造影剂用于影像引导光热溶栓。
Near-Infrared II Agent with Excellent Overall Performance for Imaging-Guided Photothermal Thrombolysis.
机构信息
State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China.
Center for Aggregation-Induced Emission, AIE Institute, South China University of Technology, Guangzhou 510640, China.
出版信息
ACS Nano. 2024 Sep 10;18(36):25144-25154. doi: 10.1021/acsnano.4c06965. Epub 2024 Aug 27.
Near-infrared II (NIR-II) imaging and photothermal therapy hold tremendous potential in precision diagnosis and treatment within biological organisms. However, a significant challenge is the shortage of NIR-II fluorescent probes with both high photothermal conversion coefficient (PCE) and fluorescence quantum yield (Φ). Herein, we address this issue by integrating a large conjugated electron-withdrawing core, multiple rotors, and multiple alkyl chains into a molecule to successfully generate a NIR-II agent 4THTPB with excellent PCE (87.6%) and high Φ (3.2%). 4THTPB shows a maximum emission peak at 1058 nm, and the emission tail could extend to as long as 1700 nm. These characteristics make its nanoparticles (NPs) perform well in NIR-II high-resolution angiography, thereby allowing for precise diagnosis of thrombus through NIR-II imaging and enabling efficient photothermal thrombolysis. This work not only furnishes a NIR-II agent with excellent overall performance but also provides valuable guidance for the design of high-performance NIR-II agents.
近红外二区（NIR-II）成像是一种在生物体内进行精准诊断和治疗的新兴技术，光热治疗在该领域也具有巨大的应用潜力。然而，目前面临的一个重大挑战是缺乏同时具有高光热转换效率（PCE）和高光荧光量子产率（Φ）的近红外二区荧光探针。本文通过将大的共轭电子给体核心、多个旋转体和多个烷基链集成到一个分子中，成功地合成了一种具有优异 PCE（87.6%）和高 Φ（3.2%）的 NIR-II 试剂 4THTPB。4THTPB 的最大发射峰位于 1058nm，发射尾巴可以延伸到 1700nm 长。这些特性使得其纳米颗粒（NPs）在近红外二区高分辨率血管造影中表现出色，从而可以通过近红外二区成像进行精确的血栓诊断，并实现高效的光热溶栓。这项工作不仅提供了一种具有优异综合性能的 NIR-II 试剂，还为高性能 NIR-II 试剂的设计提供了有价值的指导。
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