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使用治疗权重逆概率法(IPTW)评估阴部神经阻滞对亚洲人群痔切除术后急性疼痛的疗效。

Effectiveness of pudendal nerve block in the management of acute post-haemorrhoidectomy pain in Asian individuals using inverse probability of treatment weighting (IPTW).

作者信息

Chen Chang-Cyuan, Chang Kuei-Ting, Lee Yuan-Wen, Chen Juan-Syun, Wei Po-Li, Chang Chia-Li, Huang Yan-Jiun

机构信息

Department of Medical Education, Taipei Medical University Hospital, Taipei City, Taiwan.

Department of Medical Education, Chang Gung Memorial Hospital, Chiayi County, Taiwan.

出版信息

Asian J Surg. 2024 Aug 26. doi: 10.1016/j.asjsur.2024.07.270.

Abstract

BACKGROUND

Inadequate management of acute post-haemorrhoidectomy pain is a major concern. Optimal pain management is necessary to reduce acute postoperative pain and improve care quality. Therefore, we investigated the efficacy of postoperative pudendal nerve block (PNB) in reducing acute post-haemorrhoidectomy pain in Asian individuals.

METHODS

This retrospective cohort study analysed 108 adult patients with grade 3 haemorrhoids. Patients with anorectal cancer were excluded from this study. Among the 108 patients, 79 and 29 received spinal anaesthesia (SA) with PNB (SAPNB) and SA alone, respectively. Propensity score matching and inverse probability of treatment weighting were performed to adjust for the effects of confounders.

RESULTS

Patients receiving SAPNB had significantly lower postoperative pain scores 6, 12, and 18 h after haemorrhoidectomy but significantly higher postoperative pain scores 24 and 48 h after haemorrhoidectomy than did patients receiving SA alone. PNB, older age, female sex, reduced operation time, and absence of cardiovascular disease reduced the risk of moderate to severe postoperative pain. Only the addition of PNB was consistently associated with a reduced risk of moderate to severe pain 6, 12, and 18 h after haemorrhoidectomy. Patients receiving SAPNB had significantly lower risks of perianal swelling and urinary retention but a significantly higher risk of nausea than did those receiving SA alone. The two groups exhibited similarity in their rates of postoperative readmission because of poor pain management and their lengths of stay upon readmission.

CONCLUSION

The addition of PNB to SA may effectively reduce acute post-haemorrhoidectomy pain.

摘要

背景

痔切除术后急性疼痛管理不当是一个主要问题。优化疼痛管理对于减轻术后急性疼痛和提高护理质量至关重要。因此,我们研究了术后阴部神经阻滞(PNB)在减轻亚洲人群痔切除术后急性疼痛方面的疗效。

方法

这项回顾性队列研究分析了108例3级痔疮成年患者。肛管直肠癌患者被排除在本研究之外。在这108例患者中,分别有79例和29例接受了联合PNB的脊髓麻醉(SAPNB)和单纯脊髓麻醉(SA)。进行倾向评分匹配和治疗权重逆概率分析以调整混杂因素的影响。

结果

与单纯接受SA的患者相比,接受SAPNB的患者在痔切除术后6、12和18小时的术后疼痛评分显著更低,但在术后24和48小时的术后疼痛评分显著更高。PNB、年龄较大、女性、手术时间缩短以及无心血管疾病可降低中度至重度术后疼痛的风险。仅PNB的添加与痔切除术后6、12和18小时中度至重度疼痛风险的降低始终相关。与单纯接受SA的患者相比,接受SAPNB的患者肛周肿胀和尿潴留的风险显著更低,但恶心的风险显著更高。两组因疼痛管理不佳导致的术后再入院率及其再入院时的住院时间相似。

结论

SA联合PNB可有效减轻痔切除术后急性疼痛。

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