鉴定与慢性鼻息肉鼻窦炎中性粒细胞相关的枢纽基因。
Identification of hub genes associated with neutrophils in chronic rhinosinusitis with nasal polyps.
机构信息
Department of Otolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, People's Republic of China.
Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai Yuhuangding Hospital, Qingdao University, Yantai, People's Republic of China.
出版信息
Sci Rep. 2024 Aug 27;14(1):19870. doi: 10.1038/s41598-024-70387-6.
Neutrophil infiltration plays a key role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). However, pertinent mechanisms remain poorly elucidated. Here, we obtained the data from gene expression omnibus (GEO) and gene set enrichment analysis (GSEA) to identify and validate neutrophil-associated hub genes in CRSwNP. We found that four neutrophil-associated hub genes, namely ICAM1, IL-1β, TYROBP, and BCL2A1, were markedly upregulated and positively correlated with neutrophil infiltration levels in patients with CRSwNP. Subsequently, this was confirmed by real-time quantitative PCR. In conclusion, we identified the role of neutrophil infiltration in the pathophysiology of CRSwNP, which may be the potential targets for the diagnosis and treatment of CRSwNP.
中性粒细胞浸润在伴有鼻息肉的慢性鼻-鼻窦炎（CRSwNP）的发病机制中起关键作用。然而，相关机制仍未得到充分阐明。在这里，我们从基因表达综合数据库（GEO）和基因集富集分析（GSEA）中获取数据，以鉴定和验证 CRSwNP 中与中性粒细胞相关的枢纽基因。我们发现，四个与中性粒细胞相关的枢纽基因，即 ICAM1、IL-1β、TYROBP 和 BCL2A1，在 CRSwNP 患者中明显上调，并与中性粒细胞浸润水平呈正相关。随后，这一结果通过实时定量 PCR 得到了证实。总之，我们确定了中性粒细胞浸润在 CRSwNP 病理生理学中的作用，这可能是 CRSwNP 诊断和治疗的潜在靶点。
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