Copenhagen Research Center for Autoimmune Connective Tissue Diseases (COPEACT), Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.
Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Rheumatol Int. 2024 Oct;44(10):1909-1921. doi: 10.1007/s00296-024-05698-y. Epub 2024 Aug 27.
Myositis is associated with reduced quality of life, which is accompanied by significant impairments in muscle endurance and strength, altogether representing cardinal traits in patients with myositis. This randomised controlled trial aimed to investigate the effect of high-intensity resistance training on quality of life in patients with myositis. Thirty-two patients with established, stable myositis were randomised to 16 weeks of high-intensity resistance training (intervention group) or 16 weeks of usual care (control group). Primary outcome was quality of life assessed as the change in the physical component summary score (PCS) of the Short Form-36 health questionnaire from baseline to post-intervention. Secondary outcomes included functional capacity measures, such as functional index 3, and International Myositis Assessment and Clinical Studies Group (IMACS) disease activity and damage core set measures, including manual muscle testing 8 (MMT8). The primary outcome PCS showed an improvement in favour of high-intensity resistance training with a between-group difference of 5.33 (95% CI 0.61; 10.05) (p = 0.03). Additionally, functional index 3 showed a between-group difference indicating greater gains with high-intensity resistance training 11.49 (95% CI 3.37; 19.60) (p = 0.04), along with a between-group improvement in MMT8 1.30 (95% CI 0.09; 2.51) (p = 0.04). High-intensity resistance training for 16 weeks effectively improved quality of life in patients with myositis. Clinical measures of muscle endurance and muscle strength were also found to improve with high-intensity resistance training, while patients stayed in disease remission. Consequently, progressively adjusted high-intensity resistance training is feasible and causes no aggravation of the disease, while benefitting patients with myositis.Clinical trial registration: Clinicaltrials.gov ID: NCT04486261- https://clinicaltrials.gov/study/NCT04486261 .
肌炎与生活质量下降有关，其伴有肌肉耐力和力量的显著损伤，这些共同构成了肌炎患者的主要特征。本随机对照试验旨在研究高强度抗阻训练对肌炎患者生活质量的影响。32 名确诊、病情稳定的肌炎患者被随机分配至 16 周的高强度抗阻训练（干预组）或 16 周的常规护理（对照组）。主要结局为从基线到干预后，使用 Short Form-36 健康问卷的身体成分综合评分（PCS）变化评估生活质量。次要结局包括功能能力测量，如功能指数 3（functional index 3）和国际肌炎评估与临床研究组（International Myositis Assessment and Clinical Studies Group，IMACS）疾病活动和损伤核心集测量，包括 8 项徒手肌力测试（manual muscle testing 8，MMT8）。主要结局 PCS 显示出有利于高强度抗阻训练的改善，组间差异为 5.33（95%CI 0.61；10.05）（p=0.03）。此外，功能指数 3 显示出组间差异，表明高强度抗阻训练有更大的获益，差异为 11.49（95%CI 3.37；19.60）（p=0.04），同时 MMT8 也有组间改善，差异为 1.30（95%CI 0.09；2.51）（p=0.04）。16 周的高强度抗阻训练有效地改善了肌炎患者的生活质量。肌肉耐力和肌肉力量的临床测量也发现随着高强度抗阻训练而改善，同时患者保持在疾病缓解状态。因此，逐步调整的高强度抗阻训练是可行的，不会加重疾病，反而使肌炎患者受益。临床试验注册：Clinicaltrials.gov 注册号：NCT04486261- https://clinicaltrials.gov/study/NCT04486261。
