Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, China.
Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China.
BMC Ophthalmol. 2024 Aug 27;24(1):379. doi: 10.1186/s12886-024-03644-x.
To assess the interactive relationship between blood pressure status and diabetic mellitus (DM) with ganglion cell complex (GCC) thickness in elderly individuals in rural China.
Participants aged 50 years and older in a rural area of Daxing District, Beijing, were recruited in this study from October 2018 to November 2018. All subjects underwent a comprehensive systemic and ocular examination. Blood pressure status was graded as normotension, controlled hypertension and uncontrolled hypertension according to blood pressure measurements and the use of any medication for hypertension treatment. GCC parameters were measured by spectral-domain optical coherence tomography (SD-OCT). Generalized linear models (GLM) adjusted for related potential confounders were used to assess the interaction between DM and blood pressure status.
Among 1415 screened subjects (2830 eyes), a total of 1117 eyes were enrolled in the final analysis. GLM analysis showed a significant interactive relationship between DM with uncontrolled hypertension status (β = 3.868, p = 0.011). GCC thickness would decrease 0.255 μm per year as the age increased (β=-0.255, p < 0.001). In a subgroup of 574 subjects with uncontrolled hypertension, DM was associated with an increased average of GCC thickness (β = 1.929, p = 0.022).
The present results revealed a significant interactive relationship between blood pressure status and DM. The average GCC thickness increased in individuals with DM combined with uncontrolled hypertension, which should be considered in the measurement of GCC. Further studies are warranted to explore ganglion cells changes as a non-invasive method to detect neuron alterations in individuals with DM and uncontrolled hypertension.
The registration number of the present trial in the Chinese Clinical Trial Registry is ChiCTR2000037944.
评估中国农村老年人血压状况与糖尿病（DM）和节细胞复合体（GCC）厚度之间的交互关系。
本研究于 2018 年 10 月至 11 月在北京大兴区农村地区招募年龄在 50 岁及以上的参与者。所有受试者均接受全面的全身和眼部检查。根据血压测量值和使用任何高血压治疗药物，将血压状况分为正常血压、控制良好的高血压和未控制的高血压。采用频域光相干断层扫描（SD-OCT）测量 GCC 参数。使用广义线性模型（GLM）调整相关潜在混杂因素，评估 DM 与血压状况之间的交互作用。
在筛选出的 1415 名受试者（2830 只眼）中，共有 1117 只眼纳入最终分析。GLM 分析显示，DM 与未控制的高血压状态之间存在显著的交互关系（β=3.868，p=0.011）。GCC 厚度随年龄增长每年减少 0.255μm（β=-0.255，p<0.001）。在 574 名未控制高血压的亚组中，DM 与 GCC 厚度的平均增加有关（β=1.929，p=0.022）。
本研究结果显示血压状况与 DM 之间存在显著的交互关系。未控制高血压合并 DM 的个体 GCC 厚度平均增加，这在测量 GCC 时应予以考虑。需要进一步的研究来探索作为一种非侵入性方法检测 DM 和未控制高血压个体神经元改变的节细胞变化。
本研究在中国临床试验注册中心的注册号为 ChiCTR2000037944。
