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非编码 RNA 对癌症耐药性中铁死亡的表观遗传修饰。

Epigenetic modification of ferroptosis by non-coding RNAs in cancer drug resistance.

机构信息

Department of Geriatrics, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, 100049, China.

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 11439, USA.

出版信息

Mol Cancer. 2024 Aug 27;23(1):177. doi: 10.1186/s12943-024-02088-7.

DOI:10.1186/s12943-024-02088-7
PMID:39192329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11348582/
Abstract

The development of drug resistance remains a major challenge in cancer treatment. Ferroptosis, a unique type of regulated cell death, plays a pivotal role in inhibiting tumour growth, presenting new opportunities in treating chemotherapeutic resistance. Accumulating studies indicate that epigenetic modifications by non-coding RNAs (ncRNA) can determine cancer cell vulnerability to ferroptosis. In this review, we first summarize the role of chemotherapeutic resistance in cancer growth/development. Then, we summarize the core molecular mechanisms of ferroptosis, its upstream epigenetic regulation, and its downstream effects on chemotherapeutic resistance. Finally, we review recent advances in understanding how ncRNAs regulate ferroptosis and from such modulate chemotherapeutic resistance. This review aims to enhance general understanding of the ncRNA-mediated epigenetic regulatory mechanisms which modulate ferroptosis, highlighting the ncRNA-ferroptosis axis as a key druggable target in overcoming chemotherapeutic resistance.

摘要

耐药性的发展仍然是癌症治疗的主要挑战。铁死亡作为一种独特的细胞死亡方式，在抑制肿瘤生长中起着关键作用，为治疗化疗耐药性提供了新的机会。越来越多的研究表明，非编码 RNA (ncRNA) 的表观遗传修饰可以决定癌细胞对铁死亡的敏感性。在这篇综述中，我们首先总结了化疗耐药性在癌症生长/发展中的作用。然后，我们总结了铁死亡的核心分子机制、其上游表观遗传调控以及对化疗耐药性的下游影响。最后，我们综述了近年来对 ncRNA 如何调节铁死亡以及由此调节化疗耐药性的理解进展。本综述旨在增强对 ncRNA 介导的调节铁死亡的表观遗传调控机制的一般认识，强调 ncRNA-铁死亡轴作为克服化疗耐药性的关键可药物靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/5551d477c0d0/12943_2024_2088_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/ae87b9ff987f/12943_2024_2088_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/ad575c24926b/12943_2024_2088_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/339270419ebb/12943_2024_2088_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/ddaaac6ed921/12943_2024_2088_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/9c8df606e7b5/12943_2024_2088_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/5551d477c0d0/12943_2024_2088_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/ae87b9ff987f/12943_2024_2088_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/ad575c24926b/12943_2024_2088_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/339270419ebb/12943_2024_2088_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/ddaaac6ed921/12943_2024_2088_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/9c8df606e7b5/12943_2024_2088_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/11348582/5551d477c0d0/12943_2024_2088_Fig6_HTML.jpg

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Hypoxia-induced epigenetic regulation of miR-485-3p promotes stemness and chemoresistance in pancreatic ductal adenocarcinoma via SLC7A11-mediated ferroptosis.缺氧诱导的miR-485-3p表观遗传调控通过SLC7A11介导的铁死亡促进胰腺导管腺癌的干性和化疗耐药性。
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