Ma Yue, Li Jia-Jia
Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province, China.
Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province, China. E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2024 Aug;32(4):1011-1017. doi: 10.19746/j.cnki.issn.1009-2137.2024.04.006.
To investigate the expression and clinical significance of long noncoding RNA(lncRNA) HEIH in patients with acute myeloid leukemia (AML).
50 newly diagnosed AML patients (except M3) admitted to the First Affiliated Hospital of Bengbu Medical College from January 2019 to December 2020 were included in the study, with 30 patients with non-hematological malignancies as controls. The relative expression level of lncRNA HEIH in all patients were detected, the correlation of clinical characteristics, gene mutations, FAB classification, efficacy, prognosis and overall survival (OS) of AML patients with the expression level of lncRNA HEIH were analyzed.
The expression level of lncRNA HEIH in AML patients was significantly higher than that in patients with non-hematological malignancies ( <0.01). Moreover, AML patients with high white blood cell count (WBC), and mutations, poor efficacy, and poor prognosis often showed higher expression of lncRNA HEIH, and patients with high lncRNA HEIH expression showed a shorter overall survival (OS).
lncRNA HEIH shows an unique molecular biological significance in AML patients, which may provide a new approach for diagnosis, monitoring and targeted therapy of AML.
探讨长链非编码RNA（lncRNA）HEIH在急性髓系白血病（AML）患者中的表达及临床意义。
纳入2019年1月至2020年12月蚌埠医学院第一附属医院收治的50例新诊断AML患者（M3除外），以30例非血液系统恶性肿瘤患者作为对照。检测所有患者lncRNA HEIH的相对表达水平，分析AML患者lncRNA HEIH表达水平与临床特征、基因突变、FAB分型、疗效、预后及总生存期（OS）的相关性。
AML患者lncRNA HEIH表达水平显著高于非血液系统恶性肿瘤患者（<0.01）。此外，白细胞计数（WBC）高、有 突变、疗效差及预后差的AML患者lncRNA HEIH表达往往较高，lncRNA HEIH高表达患者的总生存期（OS）较短。
lncRNA HEIH在AML患者中具有独特的分子生物学意义，可能为AML的诊断、监测及靶向治疗提供新途径。
