Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Liaoning Clinical Research Center for Laboratory Medicine, Shenyang, China.
Virulence. 2024 Dec;15(1):2387180. doi: 10.1080/21505594.2024.2387180. Epub 2024 Aug 27.
is a common pathogen associated with community-acquired bacterial meningitis, characterized by high morbidity and mortality rates. While vaccination reduces the incidence of meningitis, many survivors experience severe brain damage and corresponding sequelae. The pathogenesis of pneumococcal meningitis has not been fully elucidated. Currently, meningitis requires bacterial disruption of the blood - brain barrier, a process that involves the interaction of bacterial surface components with host cells and various inflammatory responses. This review delineates the global prevalence, pathogenesis, and treatment strategies of pneumococcal meningitis. The objective is to enhance the thorough comprehension of the clinical manifestations and biological mechanisms of the disease, thereby enabling more efficient prevention, diagnosis, and therapeutic interventions.
是一种常见的与社区获得性细菌性脑膜炎相关的病原体，其特征是发病率和死亡率高。虽然疫苗接种降低了脑膜炎的发病率，但许多幸存者仍经历严重的脑损伤和相应的后遗症。肺炎球菌性脑膜炎的发病机制尚未完全阐明。目前，脑膜炎需要细菌破坏血脑屏障，这一过程涉及细菌表面成分与宿主细胞的相互作用以及各种炎症反应。本综述阐述了肺炎球菌性脑膜炎的全球流行情况、发病机制和治疗策略。目的是增强对该疾病临床表现和生物学机制的全面理解，从而更有效地进行预防、诊断和治疗干预。
