[幽门螺杆菌感染诱导的癌相关成纤维细胞对胃上皮-间质转化影响的研究进展]
[Progress on the effects of cancer-related fibroblast induced by Helicobacter pylori infection on gastric epithelial-mesenchymal transition].
作者信息
Li Yi-Lin, Zheng Li-Fei
机构信息
School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
出版信息
Sheng Li Xue Bao. 2024 Aug 25;76(4):547-560.
Helicobacter pylori (Hp) is a Gram-negative bacterium that colonizes in the gastric mucosa. Hp induces the production of cancer-associated fibroblasts (CAF) in the stomach. The virulence factors of Hp and CAF trigger epithelial-mesenchymal transition (EMT), leading to local inflammation, damage to the gastric mucosa, and the occurrence of chronic gastritis. Here, we summarize the molecular mechanisms of CAF mediated gastric EMT after Hp infection, providing new insights into potential molecular targets and strategies for the future treatment of Hp infection associated gastric cancer.
幽门螺杆菌（Hp）是一种定植于胃黏膜的革兰氏阴性菌。Hp可诱导胃中癌相关成纤维细胞（CAF）的产生。Hp的毒力因子和CAF会引发上皮-间质转化（EMT），导致局部炎症、胃黏膜损伤以及慢性胃炎的发生。在此，我们总结了Hp感染后CAF介导胃EMT的分子机制，为未来治疗Hp感染相关胃癌的潜在分子靶点和策略提供了新的见解。
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