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维生素D和硒用于治疗伴有桥本甲状腺炎的2型糖尿病:剂量和疗程见解

Vitamin D and selenium for type 2 diabetes mellitus with Hashimoto's thyroiditis: Dosage and duration insights.

作者信息

Yu Yun-Feng, Shangguan Xue-Li, Tan Dan-Ni, Qin Li-Na, Yu Rong

机构信息

School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China.

出版信息

World J Diabetes. 2024 Aug 15;15(8):1824-1828. doi: 10.4239/wjd.v15.i8.1824.

DOI:10.4239/wjd.v15.i8.1824
PMID:39192860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11346084/
Abstract

This letter discusses the publication by Feng . Iodine, selenium, and vitamin D are closely associated with thyroid hormone production in humans; however, the efficacy of selenium and vitamin D supplementation for type 2 diabetes mellitus (T2DM) patients with Hashimoto's thyroiditis (HT) remains controversial. In the retrospective study we discuss herein, the authors highlighted significant improvements in thyroid function, thyroid antibodies, blood glucose, and blood lipid in T2DM patients with HT following addition of vitamin D and selenium to their antidiabetic regimens, underscoring the value of these supplements. Our team is currently engaged in research exploring the relationship between micronutrients and HT, and we have obtained invaluable insights from the aforementioned study. Based on this research and current literature, we recommend a regimen of 4000 IU/day of vitamin D and 100-200 μg/day of selenium for over three months to six months for patients with HT, particularly for those with concurrent T2DM.

摘要

这封信讨论了冯的出版物。碘、硒和维生素D与人体甲状腺激素的产生密切相关;然而,补充硒和维生素D对患有桥本甲状腺炎(HT)的2型糖尿病(T2DM)患者的疗效仍存在争议。在我们在此讨论的回顾性研究中,作者强调,在抗糖尿病治疗方案中添加维生素D和硒后,患有HT的T2DM患者的甲状腺功能、甲状腺抗体、血糖和血脂有显著改善,凸显了这些补充剂的价值。我们的团队目前正在进行探索微量营养素与HT之间关系的研究,并且我们从上述研究中获得了宝贵的见解。基于这项研究和当前文献,我们建议HT患者,特别是并发T2DM的患者,服用为期三个多月至六个月的每日4000国际单位维生素D和每日100 - 200微克硒的治疗方案。

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本文引用的文献

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World J Diabetes. 2024 Feb 15;15(2):209-219. doi: 10.4239/wjd.v15.i2.209.
2
Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.桥本甲状腺炎患者补硒:随机临床试验的系统评价和荟萃分析。
Thyroid. 2024 Mar;34(3):295-313. doi: 10.1089/thy.2023.0556. Epub 2024 Feb 16.
3
Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.维生素 D 补充对桥本甲状腺炎患者自身抗体和甲状腺功能的影响:系统评价和荟萃分析。
Medicine (Baltimore). 2023 Dec 29;102(52):e36759. doi: 10.1097/MD.0000000000036759.
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Effects of vitamin D on thyroid autoimmunity markers in Hashimoto's thyroiditis: systematic review and meta-analysis.维生素 D 对桥本甲状腺炎甲状腺自身免疫标志物的影响:系统评价和荟萃分析。
J Int Med Res. 2021 Dec;49(12):3000605211060675. doi: 10.1177/03000605211060675.
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Insufficient evidence to support the clinical efficacy of selenium supplementation for patients with chronic autoimmune thyroiditis.没有足够的证据支持硒补充剂对慢性自身免疫性甲状腺炎患者的临床疗效。
Endocrine. 2021 Aug;73(2):384-397. doi: 10.1007/s12020-021-02642-z. Epub 2021 Mar 27.
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