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糖尿病对尿路感染患者尿病原菌谱及抗菌药物耐药性的影响。

Effect of Diabetes Mellitus on the Spectrum of Uropathogens and the Antimicrobial Resistance in Patients with Urinary Tract Infection.

机构信息

Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

Clinical Research Development Unit, Kowsar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.

出版信息

Arch Razi Inst. 2024 Feb 1;79(1):92-101. doi: 10.32592/ARI.2024.79.1.92. eCollection 2024 Feb.

Abstract

Patients with diabetes mellitus frequently experience urinary tract infections (UTIs). In the present study, we looked at how glycemic control affects diabetic patients' rates of UTI, the causing pathogens, the presence of multi-drug-resistant (MDR) and extensively drug-resistant organisms, and the infections' relation to diabetes. Diabetes patients' midstream urine samples were included, after collecting and identifying the organisms, disc diffusion antibiotic sensitivity tests were conducted. The HbA1c was measured for all patients. A total of 500 diabetic patients provided urine samples for this study, and 189 (37.2%) of them had UTIs. Compared to 59 patients with managed glycemia, 130 individuals in the uncontrolled glycemic group experienced the most UTI cases. In both diabetic groups, females had a significantly higher prevalence of UTI than males (88.4% and 11.6%, respectively). The most common bacterial isolate, , displayed 58.4% MDR. Regardless of age or gender, glycemic control in diabetes patients is essential for decreasing UTI rates.

摘要

糖尿病患者常发生尿路感染(UTI)。在本研究中,我们研究了血糖控制如何影响糖尿病患者 UTI 的发生率、病原体、多药耐药(MDR)和广泛耐药菌的存在以及感染与糖尿病的关系。收集并鉴定病原体后,对糖尿病患者的中段尿样进行了纸片扩散抗生素药敏试验。所有患者均检测了 HbA1c。本研究共纳入 500 例糖尿病患者,其中 189 例(37.2%)发生 UTI。与血糖控制良好的 59 例患者相比,血糖控制不佳组的 130 例患者 UTI 发生率最高。在两个糖尿病组中,女性 UTI 的患病率明显高于男性(分别为 88.4%和 11.6%)。最常见的细菌分离株 ,显示出 58.4%的 MDR。无论年龄或性别如何,控制糖尿病患者的血糖对于降低 UTI 发生率至关重要。

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Urinary tract infections in patients with diabetes treated with dapagliflozin.达格列净治疗糖尿病患者的尿路感染。
J Diabetes Complications. 2013 Sep-Oct;27(5):473-8. doi: 10.1016/j.jdiacomp.2013.05.004. Epub 2013 Jul 10.

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