Department anaerobic bacterial vaccine Production and Research, Clostridia Research laboratory, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
Department of Food Hygiene, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Arch Razi Inst. 2024 Feb 1;79(1):168-179. doi: 10.32592/ARI.2024.79.1.168. eCollection 2024 Feb.
Johne's disease (JD) affects domestic and wild animals across the globe. Paratuberculosis exerts huge economic impacts on the animal industry. Despite significant economic losses, little knowledge is available on the epidemiological status of Paratuberculosis in the animal population of Iran. The present study aimed to evaluate the prevalence rate of this disease in the Iranian animal population with confidence interval (CI) and p-value. The search was conducted on and screened the electronic international and national databases. Thereafter, sufficient and relevant data were extracted. Data were analyzed in STATA software (version 14). Prevalence disease rates were determined using random effect models. A total of 52 articles were included in the systematic review. According to the results, the overall disease incidence rate in Iran was 20.39%. The prevalence rate of JD was 22.33% (95% CI, 18.87-25.78) in the cattle population and 25.61% (95% CI, 21.43-29.78) in sheep. This study pinpointed that cattle and sheep were the most commonly infected hosts. The highest prevalence rate of disease was 35.88% in Tehran (95% CI, 16.77-54.99), followed by 32.86% (95% CI, 25.07-40.65), and 20.10% (95% CI, 14.63-25.58) in Khorasan Razavi and Kerman, respectively. The lowest prevalence rate of JD was 2.27% in Ilam (95% CI, 0.84-3.70). Based on this result, molecular-based methods were properly compared to other diagnostic methods. This study reported subsp. (MAP) prevalence in dairy herds in the provinces of Iran. The infection transmission from animal sources to humans and the potential role of MAP in human disease highlight a critical need for further study on this issue.
约氏病（JD）影响全球的家畜和野生动物。副结核病对动物产业造成了巨大的经济影响。尽管经济损失巨大，但人们对伊朗动物群体中副结核病的流行病学状况知之甚少。本研究旨在评估该疾病在伊朗动物群体中的流行率，并给出置信区间（CI）和 p 值。搜索和筛选了国际和国家电子数据库。然后，提取了足够和相关的数据。数据在 STATA 软件（版本 14）中进行分析。使用随机效应模型确定疾病的流行率。共有 52 篇文章纳入系统评价。结果显示，伊朗的总疾病发病率为 20.39%。牛群中 JD 的总体发病率为 22.33%（95%CI，18.87-25.78），绵羊为 25.61%（95%CI，21.43-29.78）。本研究指出，牛和羊是最常感染的宿主。疾病的最高流行率为 35.88%，在德黑兰（95%CI，16.77-54.99），其次是 32.86%（95%CI，25.07-40.65）和 20.10%（95%CI，14.63-25.58），在霍拉桑拉扎维和克尔曼。JD 的最低流行率为 2.27%，在伊拉姆（95%CI，0.84-3.70）。根据这一结果，分子方法与其他诊断方法进行了适当比较。本研究报告了伊朗各省奶牛场副结核病亚种（MAP）的流行情况。动物源向人类的感染传播以及 MAP 在人类疾病中的潜在作用，突显了进一步研究这一问题的迫切需要。
