Kyriacou C P, Hall J C
Nature. 1985;314(6007):171-3. doi: 10.1038/314171a0.
The Drosophila melanogaster male produces a species-specific courtship song by wing vibration. The most conspicuous feature of the song is a series of pulses with a 30-40-ms interpulse interval (IPI) which oscillate in wild-type males with a period of 50-60 s. This short-term biological rhythm in IPI is influenced by several gene mutations at the period (per) locus, which alter the normal 24-h free-running period of the circadian clock and have corresponding effects on the song cycle. The present study reveals that, under restrictive conditions, temperature-sensitive mutations which affect neuronal membrane excitability seem to stop the biological clock underlying the fruitfly's song rhythm.
黑腹果蝇雄性通过翅膀振动产生一种物种特异性的求偶歌。这种歌最显著的特征是一系列脉冲，脉冲间隔（IPI）为30 - 40毫秒，在野生型雄性中以50 - 60秒的周期振荡。IPI中的这种短期生物节律受到周期（per）基因座处的几个基因突变的影响，这些突变改变了生物钟正常的24小时自由运行周期，并对歌的周期产生相应影响。本研究表明，在限制性条件下，影响神经元膜兴奋性的温度敏感突变似乎会使果蝇歌节律背后的生物钟停止运行。
