Zhan R, Yao Y X, Gong C C, Zhang Y S, Deng L F
Department of Pathology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou 215200, China.
Department of Pathology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Zhonghua Yi Xue Za Zhi. 2024 Sep 3;104(34):3252-3255. doi: 10.3760/cma.j.cn112137-20240311-00547.
To explore the clinical and pathological characteristics of squamous cell carcinoma arising in ovary mature cystic teratoma (MCT) and primary ovarian squamous cell carcinoma (POSCC). Retrospective analysis was conducted on the clinical and pathological characteristics, immunophenotype and prognosis of five cases of ovarian squamous cell carcinoma (OSCC). Next generation sequencing (NGS) test was performed on one case of POSCC to analyze its molecular genetic characteristics. The age of five patients (including four MCTs and one POSCC) ranged from 43 to 68 years. There were one case of simultaneous involvement of both ovaries, one case of left ovary, and three cases of right ovary. Microscopically, four cases of tumors were composed of MCT and squamous cell carcinoma. Among which, one case only showed squamous cell carcinoma components and no accompanying lesions were found in the surrounding area. Immunohistochemistry staining showed that all cases were positive for p40, CK5/6, p63; P53 was positively expressed in two cases; and the proliferation index Ki-67 ranged from 30% to 50%. One POSCC NGS test harbored 12 somatic mutations, among which 3 mutations with clear or potential clinical significance were BRCA1 gene (p.G263fs), TP53 gene (p.R273C), and ERBB2 gene (copy number amplification). Four patients underwent ovarian cancer debulking surgery; one patient underwent radical resection of ovarian cancer and platinum-based chemotherapy was given after surgery. During 3-10 months of follow-up, 3 patients died; 1 patient was alive; and 1 patient was lost to follow-up. OSCC is a kind of ovarian cancer with low incidence rate. Most of these tumors arise from malignant transformation of MCT. POSCC is extremely rare. The treatment mainly involves surgical resection, supplemented by platinum-based combination chemotherapy after surgery. OSCC progresses rapidly, and has a poor prognosis.
探讨卵巢成熟性囊性畸胎瘤（MCT）来源的鳞状细胞癌及原发性卵巢鳞状细胞癌（POSCC）的临床及病理特征。对5例卵巢鳞状细胞癌（OSCC）的临床病理特征、免疫表型及预后进行回顾性分析。对1例POSCC进行二代测序（NGS）检测以分析其分子遗传学特征。5例患者（包括4例MCT来源及1例POSCC）年龄为43至68岁。双侧卵巢同时受累1例，左侧卵巢1例，右侧卵巢3例。镜下，4例肿瘤由MCT和鳞状细胞癌组成。其中，1例仅见鳞状细胞癌成分，周围未见伴发病变。免疫组化染色显示，所有病例p40、CK5/6、p63均阳性；2例P53阳性表达；增殖指数Ki-67为30%至50%。1例POSCC的NGS检测发现12个体细胞突变，其中具有明确或潜在临床意义的3个突变分别为BRCA1基因（p.G263fs）、TP53基因（p.R273C）和ERBB2基因（拷贝数扩增）。4例患者接受了卵巢癌减瘤手术；1例患者接受了卵巢癌根治性切除术，术后给予铂类化疗。随访3至10个月，3例患者死亡；1例存活；1例失访。OSCC是一种发病率较低的卵巢癌。这些肿瘤大多源于MCT的恶变。POSCC极为罕见。治疗主要包括手术切除，术后辅以铂类联合化疗。OSCC进展迅速，预后较差。
