. Laboratório de Bacteriologia, Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba (PR) Brasil.
. Faculdades e Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba (PR) Brasil.
J Bras Pneumol. 2024 Aug 26;50(4):e20240026. doi: 10.36416/1806-3756/e20240026. eCollection 2024.
Thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus are being isolated with increasing frequency from patients with cystic fibrosis (CF). The aim of this study was to evaluate the relationship between TD-SCV isolation and pulmonary function in patients with CF, as well as to determine whether the emergence of TD-SCVs was associated with trimethoprim-sulfamethoxazole (TMP-SMX) use and with coinfection with other microorganisms.
This was a retrospective case-control study including patients with CF who visited the Clinical Hospital Complex of the Federal University of Paraná, in Curitiba, Brazil, between 2013 and 2022. Demographic, clinical, and spirometric data, as well as information on TD-SCVs and other isolated microorganisms, were collected from the medical records of patients with CF and TD-SCVs (TD-SCV group; n = 32) and compared with those of a matched group of patients with CF without TD-SCVs (control group; n = 64).
Isolation of TD-SCVs was positively associated with TMP-SMX use (p = 0.009), hospitalization (p < 0.001), and impaired pulmonary function (p = 0.04).
The use of TMP-SMX seems to contribute to the emergence of TD-SCVs, the isolation of which was directly associated with worse pulmonary function in our sample.
金黄色葡萄球菌胸苷依赖性小菌落变种（TD-SCVs）正越来越频繁地从囊性纤维化（CF）患者中分离出来。本研究旨在评估 CF 患者中 TD-SCV 分离与肺功能之间的关系，以及 TD-SCVs 的出现是否与甲氧苄啶-磺胺甲噁唑（TMP-SMX）的使用以及与其他微生物的合并感染有关。
这是一项回顾性病例对照研究，纳入了 2013 年至 2022 年期间在巴西库里蒂巴的联邦大学临床医院就诊的 CF 患者。从 CF 患者的病历中收集了人口统计学、临床和肺功能数据，以及关于 TD-SCVs 和其他分离微生物的信息，并将这些数据与无 TD-SCVs 的 CF 患者（对照组；n=64）进行了比较。
TD-SCVs 的分离与 TMP-SMX 的使用（p=0.009）、住院（p<0.001）和肺功能受损（p=0.04）呈正相关。
TMP-SMX 的使用似乎有助于 TD-SCVs 的出现，在我们的样本中，TD-SCVs 的分离与更差的肺功能直接相关。
