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用于阿尔茨海默病导致轻度认知障碍的运动研究的心肺功能评估。

Cardiorespiratory Fitness Assessment for Exercise Research in Mild Cognitive Impairment Due to Alzheimer's Disease.

出版信息

J Gerontol Nurs. 2024 Sep;50(9):31-36. doi: 10.3928/00989134-20240809-07. Epub 2024 Sep 1.

DOI:10.3928/00989134-20240809-07
PMID:39194322
Abstract

PURPOSE

To analyze cardiorespiratory fitness (CRF) levels using the gold-standard, laboratory-based cardiopulmonary exercise test (CPET) in community-dwelling older adults ( = 145) with amnestic mild cognitive impairment (aMCI), specifically CPET feasibility, CRF prediction, and CRF status in comparison to published sedentary, cognitively normal, age- and sex-adjusted normative data.

METHOD

Peak oxygen consumption (VO [mL/kg/min]) was assessed by CPET, which was categorized as submaximal, near-maximal, or maximal tests. VO predicted was compared to VO measured to assess its utility. Data were analyzed with tests.

RESULTS

Participants' mean age was 73.77 years ( = 5.74 years), with 51.7% males, 91.7% Caucasian, 68.3% married, and 16.9 years ( = 2.88 years) of education. Mean VO measured was 17.07 ( = 4.92) for the total sample (18.29 [ = 4.64] for males, 15.78 [ = 4.91] for females). Sixteen (11.03%) CPETs were submaximal, 53 (36.55%) were near-maximal, and 76 (52.41%) were maximal. Mean VO predicted was 28.59 ( = 21.94) for the total sample (29.36 [ = 22.3] for males, 27.76 [ = 21.68] for females) and was significantly higher than VO measured ( < 0.0001). Among participants with maximal CPETs, VO measured was significantly lower than sedentary normative data ( < 0.0001).

CONCLUSION

CPET was feasible for older adults with aMCI. VO predicted overly inflates CRF estimates. Low levels of CRF in older adults with aMCI suggest aerobic exercise as an important intervention. [(9), 31-36.].

摘要

目的

使用基于实验室的心肺运动测试(CPET)分析社区居住的轻度认知障碍老年人(aMCI)的心肺适应能力(CRF)水平,具体包括 CPET 的可行性、CRF 的预测以及与已发表的久坐不动、认知正常、年龄和性别调整的正常数据相比的 CRF 状态。

方法

通过 CPET 评估峰值耗氧量(VO[mL/kg/min]),CPET 分为亚最大、接近最大或最大测试。将预测的 VO 与测量的 VO 进行比较,以评估其效用。使用 检验进行数据分析。

结果

参与者的平均年龄为 73.77 岁( = 5.74 岁),其中 51.7%为男性,91.7%为白种人,68.3%已婚,受教育年限为 16.9 年( = 2.88 年)。总样本的平均 VO 测量值为 17.07( = 4.92)(男性为 18.29[ = 4.64],女性为 15.78[ = 4.91])。16 项 CPET 为亚最大,53 项为接近最大,76 项为最大。总样本的平均 VO 预测值为 28.59( = 21.94)(男性为 29.36[ = 22.3],女性为 27.76[ = 21.68]),明显高于 VO 测量值( < 0.0001)。在进行最大 CPET 的参与者中,VO 测量值明显低于久坐不动的正常数据( < 0.0001)。

结论

CPET 适用于患有 aMCI 的老年人。预测的 VO 过高估计了 CRF 估计值。患有 aMCI 的老年人 CRF 水平较低表明有氧运动是一种重要的干预措施。[(9),31-36]。

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