Prieto-Matos Carlos, Rey-Martínez Jorge, Pérez-Fernández Nicolás
ENT Department, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Neurotology Unit, ENT Department, Hospital Universitario Donostia, 20014 Donostia-San Sebastián, Spain.
Audiol Res. 2024 Aug 22;14(4):747-759. doi: 10.3390/audiolres14040063.
The aim of this study is to calculate the gains of the quantified visually enhanced vestibulo-ocular reflex (qVVOR) and the quantified vestibulo-ocular reflex suppression (qVORS), using a specific system to generate a visual suppression index (SI) in healthy subjects obtained through the gains of qVVOR and qVORS, and to determine the normal values of the index, as well as the influence of age and sex variables on the SI.
This prospective observational clinical study includes 83 healthy subjects who underwent the head impulse and suppression tests (HIMP and SHIMP, respectively), qVVOR, and qVORS tests, all of the vHIT. The sinusoidal tests (qVVOR and qVORS) were conducted at an intended frequency of 0.75 Hz. The gains of these tests were calculated using a system specifically designed for this purpose. A formula for the SI was established using a ratio of the gains from these tests. Two SI values are presented: unilateral, distinct for each direction of head movement, and bilateral, representing the suppression of both sides simultaneously.
Mean gains for the qVVORs were 0.981 ± 0.070 and 0.978 ± 0.077 for the rightwards and leftwards qVVORs, respectively. The gains for the suppressed tests were 0.334 ± 0.112 and 0.353 ± 0.110 for the rightwards and leftwards qVORSs, respectively. A difference of 0.05 Hz was observed between the expected (0.75 Hz) and the obtained frequency of head movement, which is statistically significant ( < 0.001). The SI was 0.342 ± 0.118 for the right side (right SI) and 0.363 ± 0.117 for the left side (left SI). The bilateral SI had a mean value of 0.295 ± 0.104. No significant differences in the SI were noted according to the subject's age. The SI for women was lower than in the case of males.
The VVOR/VORS quantification algorithm allows for the reliable calculation of the numerical gain of qVVOR and qVORS with mathematical soundness and consistency of results. Our data support the use of a single or specific measure for direction of head movement; although significant differences exist, these differences are not clinically relevant.
本研究的目的是使用特定系统计算量化视觉增强前庭眼反射（qVVOR）和量化前庭眼反射抑制（qVORS）的增益，该系统可通过qVVOR和qVORS的增益生成健康受试者的视觉抑制指数（SI），并确定该指数的正常值，以及年龄和性别变量对SI的影响。
这项前瞻性观察性临床研究纳入了83名健康受试者，他们分别接受了头部冲动和抑制测试（分别为HIMP和SHIMP）、qVVOR和qVORS测试，所有这些都是视频头脉冲测试（vHIT）。正弦测试（qVVOR和qVORS）以预期频率0.75Hz进行。这些测试的增益使用专门为此目的设计的系统进行计算。使用这些测试增益的比率建立了SI的公式。给出了两个SI值：单侧，针对每个头部运动方向不同；双侧，代表两侧同时的抑制。
右侧和左侧qVVOR的qVVOR平均增益分别为0.981±0.070和0.978±0.077。抑制测试的增益，右侧和左侧qVORS分别为0.334±0.112和0.353±0.110。观察到预期（0.75Hz）和获得的头部运动频率之间存在0.05Hz的差异，具有统计学意义（<0.001）。右侧（右SI）的SI为0.342±0.118，左侧（左SI）为0.363±0.117。双侧SI的平均值为0.295±0.104。根据受试者年龄，SI未观察到显著差异。女性的SI低于男性。
VVOR/VORS量化算法能够可靠地计算qVVOR和qVORS的数值增益，结果具有数学合理性和一致性。我们的数据支持对头部运动方向使用单一或特定测量；尽管存在显著差异，但这些差异在临床上并不相关。
