Jia Jing, Yu Chuanhe
Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Biology (Basel). 2024 Jul 29;13(8):572. doi: 10.3390/biology13080572.
Recycling histone proteins from parental chromatin, a process known as parental histone transfer, is an important component in chromosome replication and is essential for epigenetic inheritance. We review recent advances in our understanding of the recycling mechanism of parental histone H3-H4 tetramers (parH3:H4tet), emphasizing the pivotal role of the DNA replisome. In particular, we highlight the function of the MCM2-7 helicase subunit Mcm2 as a histone H3-H4 tetramer chaperone. Disruption of this histone chaperone's functions affects mouse embryonic stem cell differentiation and can lead to embryonic lethality in mice, underscoring the crucial role of the replisome in maintaining epigenomic stability.
从亲代染色质中回收组蛋白，这一过程被称为亲代组蛋白转移，是染色体复制的重要组成部分，对于表观遗传继承至关重要。我们综述了近期在理解亲代组蛋白H3-H4四聚体（parH3:H4tet）回收机制方面取得的进展，强调了DNA复制体的关键作用。特别地，我们突出了MCM2-7解旋酶亚基Mcm2作为组蛋白H3-H4四聚体伴侣蛋白的功能。这种组蛋白伴侣蛋白功能的破坏会影响小鼠胚胎干细胞分化，并可导致小鼠胚胎致死，这凸显了复制体在维持表观基因组稳定性中的关键作用。
