Department of Chemistry, Yuncheng University, Yuncheng 044000, China.
Biosensors (Basel). 2024 Aug 15;14(8):393. doi: 10.3390/bios14080393.
A precise understanding of the self-assembly kinetics of small molecules on nanoparticles (NPs) can give greater control over the size and architecture of the functionalized NPs. Herein, a single-nanoparticle electrochemical collision (SNEC)-based method was developed to monitor the self-assembly processes of 6-mercapto-1-hexanol (6-MCH) and 1-hexanethiol (MCH) on Au NPs at the single-particle level, and to investigate the self-assembly kinetics exactly. Results showed that the self-assembly processes of both consisted of rapid adsorption and slow recombination. However, the adsorption rate of MCH was significantly lower than that of 6-MCH due to the poorer polarity. Also noteworthy is that the rapid adsorption of 6-MCH on Au NPs conformed to the Langmuir model of diffusion control. Hence, the proposed SNEC-based method could serve as a complementary method to research the self-assembly mechanism of functionalized NPs.
精确理解小分子在纳米粒子（NPs）上的自组装动力学可以更好地控制功能化 NPs 的尺寸和结构。在此，开发了一种基于单纳米颗粒电化学碰撞（SNEC）的方法，用于在单颗粒水平上监测 6-巯基-1-己醇（6-MCH）和 1-己硫醇（MCH）在 Au NPs 上的自组装过程，并准确研究自组装动力学。结果表明，这两种自组装过程都包括快速吸附和缓慢重组。然而，由于极性较差，MCH 的吸附速率明显低于 6-MCH。值得注意的是，6-MCH 在 Au NPs 上的快速吸附符合扩散控制的 Langmuir 模型。因此，所提出的基于 SNEC 的方法可以作为研究功能化 NPs 自组装机制的补充方法。
