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用于室性心动过速立体定向放射消融治疗的无创标测系统:病例描述

Noninvasive Mapping System for the Stereotactic Radioablation Treatment of Ventricular Tachycardia: A Case Description.

作者信息

Romanazzi Imma, Di Monaco Antonio, Bonaparte Ilaria, Valenti Noemi, Surgo Alessia, Di Guglielmo Fiorella, Fiorentino Alba, Grimaldi Massimo

机构信息

Department of Cardiology, General Regional Hospital "F. Miulli", Acquaviva Delle Fonti, 70021 Bari, Italy.

Department of Radiation Oncology, General Regional Hospital "F. Miulli", Acquaviva Delle Fonti, 70021 Bari, Italy.

出版信息

J Cardiovasc Dev Dis. 2024 Aug 5;11(8):239. doi: 10.3390/jcdd11080239.

Abstract

OBJECTIVES

Sustained monomorphic ventricular tachycardia (SMVT) is a life-threatening condition that is often observed in patients with structural heart disease. Catheter ablation (CA) ablation is an effective and well-established treatment for the scar-related ventricular tachycardias (VTs). Sometimes, due to patient fragility or contraindications to CA, a noninvasive procedure is required. In these cases, VT ablation with stereotactic arrhythmia radioablation (STAR) for SMVTs supported by the CardioInsight mapping system seems to be a promising and effective noninvasive approach.

METHODS AND RESULTS

We report a case of a 55-year-old male smoker and heavy alcohol consumer who developed ischemic heart disease and frequent refractory SMVT relative to antiarrhythmic drugs. Catheter ablation was not practicable due to the presence of an apical thrombosis in the left ventricle. The CardioInsight system (Cardioinsight Technologies Inc., Cleveland, OH, USA) was useful for noninvasively mapping the VTs, identifying two target areas on the septum and anterior wall of the left ventricle. A personalized STAR treatment plan was carefully designed, and it was delivered in a few minutes. During follow-up, a significant reduction in the arrhythmia burden was documented.

CONCLUSIONS

Stereotactic arrhythmia radioablation supported by the CardioInsight system could be an alternative treatment for VTs when catheter ablation is not possible. Larger studies are needed to investigate this technique.

摘要

目的

持续性单形性室性心动过速(SMVT)是一种危及生命的疾病,常见于结构性心脏病患者。导管消融(CA)是治疗瘢痕相关性室性心动过速(VT)的一种有效且成熟的方法。有时,由于患者身体虚弱或存在CA的禁忌证,需要采用非侵入性手术。在这些情况下,利用CardioInsight标测系统支持的立体定向心律失常射频消融(STAR)治疗SMVT似乎是一种有前景且有效的非侵入性方法。

方法与结果

我们报告了一例55岁男性患者,有吸烟和大量饮酒史,患有缺血性心脏病,相对于抗心律失常药物,频繁发生难治性SMVT。由于左心室心尖部存在血栓,无法进行导管消融。CardioInsight系统(美国俄亥俄州克利夫兰市Cardioinsight Technologies公司)有助于对VT进行非侵入性标测,确定左心室间隔和前壁的两个靶点区域。精心设计了个性化的STAR治疗方案,并在几分钟内实施。随访期间,记录到心律失常负荷显著降低。

结论

当无法进行导管消融时,CardioInsight系统支持的立体定向心律失常射频消融可能是VT的一种替代治疗方法。需要开展更大规模的研究来探究该技术。

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