Zhang Qi, Shen Cancong, Zhang Lei, Wang Maiqiu
School of Information and Electronic Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
J Cardiovasc Dev Dis. 2024 Aug 10;11(8):247. doi: 10.3390/jcdd11080247.
Both chronic hepatitis B (CHB) and stroke contribute to a high burden of disease in the majority of low- and middle-income countries. Epidemiological studies yield conflicting results on the association between CHB and stroke, and the causal relationship remains inconclusive. This study aimed to assess the causal effects of CHB on stroke and its subtypes in East Asians by Mendelian randomization (MR) analysis. Variants associated with CHB were obtained from a genome-wide association study (GWAS) of Chinese samples as instrumental variables. The summary statistics for stroke in East Asians were derived from the largest published GWAS to date. Two-sample MR analyses were implemented to evaluate the causal effects of CHB on stroke and its subtypes by using the canonical inverse variance weighting method and other supplementary approaches. We observed an association between genetic predisposition to CHB and a decreased risk of large-artery atherosclerotic stroke (odds ratio = 0.872, 95% confidence interval = 0.786-0.967, = 0.010). The causal effects of CHB on other stroke outcomes were not statistically significant. Evidence for heterogeneity and horizontal pleiotropy were not found in our analyses. This study provides genetic evidence for a negative association between CHB and stroke in East Asians, which helps improve our understanding of the etiology of stroke.
慢性乙型肝炎（CHB）和中风在大多数低收入和中等收入国家都造成了沉重的疾病负担。流行病学研究对于CHB与中风之间的关联得出了相互矛盾的结果，因果关系仍无定论。本研究旨在通过孟德尔随机化（MR）分析评估东亚人群中CHB对中风及其亚型的因果效应。与CHB相关的变异从中国样本的全基因组关联研究（GWAS）中获取作为工具变量。东亚人群中风的汇总统计数据来自迄今为止已发表的最大规模GWAS。采用典型逆方差加权法和其他补充方法进行两样本MR分析，以评估CHB对中风及其亚型的因果效应。我们观察到CHB的遗传易感性与大动脉粥样硬化性中风风险降低之间存在关联（优势比=0.872，95%置信区间=0.786-0.967，P=0.010）。CHB对其他中风结局的因果效应无统计学意义。我们的分析未发现异质性和水平多效性的证据。本研究为东亚人群中CHB与中风之间的负相关提供了遗传学证据，有助于增进我们对中风病因的理解。
