Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Thandalam, Chennai, Tamil Nadu, 602105, India.
Neurosurg Rev. 2024 Aug 28;47(1):498. doi: 10.1007/s10143-024-02691-8.
The development of new analgesics for the management of neurosurgical pain is a great opportunity in marine environments. Particular secondary metabolites with strong biological activity that have developed for defense are produced by marine bioresources. The analgesic potential of marine-derived peptides, alkaloids, terpenes and polyketides-such as discodermolide from marine sponges and ziconotide from cone snail venom-is highlighted in this letter. These substances work through novel methods that minimize the negative effects associated with conventional analgesics while focusing on particular pain pathways. Despite obstacles in sustainable sourcing and regulatory validation, the development of these marine-derived analgesics requires interdisciplinary collaboration to fulfill their potential in enhancing pain management.
开发用于神经外科疼痛管理的新型镇痛药是海洋环境中的一个巨大机遇。海洋生物资源产生了许多具有强烈生物活性的特殊次生代谢产物，用于防御。本文重点介绍了海洋来源的肽、生物碱、萜类化合物和聚酮类化合物（如海绵来源的 discodermolide 和锥蜗牛毒液来源的 ziconotide）的镇痛潜力。这些物质通过新颖的方法发挥作用，最大限度地减少了传统镇痛药相关的负面影响，同时专注于特定的疼痛途径。尽管在可持续性资源获取和监管验证方面存在障碍，但这些海洋来源的镇痛药的开发需要跨学科合作，以充分发挥其在增强疼痛管理方面的潜力。
