Renard M, Jacobs P, Sobkowicz-Wozniak B, Kostucki W, Bernard R
Arch Mal Coeur Vaiss. 1985 Jan;78(1):37-43.
The haemodynamic effects of phentolamine, a selective alpha blocker, were studied in patients with severe mitral regurgitation and cardiac failure in the acute (Group I, 7 cases) or chronic (Group II, 7 cases) phase of myocardial infarction. After 1 hour's treatment a rise in cardiac index (+29 p. 100, p less than 0.001 and +36 p. 100, p less than 0.01), and systolic index (+19 p. 100, p less than 0.001 and +19 p. 100, p less than 0.05) were observed; the V wave of the pulmonary capillary pressure recording decreased (-32 p. 100, p less than 0.005; -26 p. 100, p less than 0.01). Oxygen transport also increased by an average of 36 p. 100, p less than 0.001, without a significant change in arterial pp O2. These results show that phentolamine improves the haemodynamics and decreases mitral regurgitation in the acute and in the chronic phases of myocardial infarction.
在心肌梗死急性期（第一组，7例）或慢性期（第二组，7例）的严重二尖瓣反流和心力衰竭患者中，研究了选择性α受体阻滞剂酚妥拉明的血流动力学效应。治疗1小时后，观察到心脏指数升高（分别升高29%，p<0.001和升高36%，p<0.01），收缩指数升高（分别升高19%，p<0.001和升高19%，p<0.05）；肺毛细血管压力记录中的V波降低（分别降低32%，p<0.005；降低26%，p<0.01）。氧输送平均增加36%，p<0.001，而动脉血氧分压无显著变化。这些结果表明，酚妥拉明可改善心肌梗死急性期和慢性期的血流动力学并减少二尖瓣反流。
