尼日利亚一家三级医疗机构中儿童肾病综合征的组织病理学特征。

Histopathologic Characteristics of Childhood Nephrotic Syndrome in a Tertiary Health Facility in Nigeria.

机构信息

Department of Paediatrics and Child Health, University of Ilorin Teaching Hospital, Ilorin. E-mail address:

Department of Pathology, University of Ilorin Teaching Hospital, Ilorin.

出版信息

West Afr J Med. 2024 May 31;41(5):493-498.

PMID:39196815

Abstract

BACKGROUND

Globally, the predominant histopathologic characteristic of childhood nephrotic syndrome has been minimal change nephropathy (MCN). However, some studies from Africa and Nigeria have revealed otherwise. It is imperative that this pattern is re-examined from time to time given changing disease and environmental dynamics from place to place.

OBJECTIVE

This study aimed to determine the histopathological characteristics of childhood nephrotic syndrome in Ilorin, northcentral Nigeria.

METHODS

A prospective study of all new patients aged 2-14 years who presented with clinical features of nephrotic syndrome between January 2010 to December 2023 at the University of Ilorin Teaching Hospital, Ilorin was carried out. All eligible patients underwent renal biopsy.

RESULTS

A total of 47 children with nephrotic syndrome were biopsied comprising of 21 males and 26 females making an M: F ratio of 1:1.2. The age range of subjects was 2-14 years with a mean of 7.8 ±3.6 years. The most common histological type of nephrotic syndrome was minimal change nephrotic syndrome (MCNS) which occurred in 35(74.5%) children followed by membranoproliferative glomerulonephritis (MPGN) in 5(10.6%) and focal segmental glomerulosclerosis (FSGS) in 2(4.3%). Of the 35 MCNS patients, 31(88.6%) were steroid sensitive while 4(11.4%) were steroid resistant.

CONCLUSION

The predominant histopathological characteristic of childhood nephrotic syndrome was minimal change nephrotic syndrome, which was mostly steroid-sensitive.

摘要

背景

在全球范围内，儿童肾病综合征的主要组织病理学特征一直是微小病变肾病（MCN）。然而，来自非洲和尼日利亚的一些研究表明并非如此。鉴于疾病和环境动态在不同地方不断变化，有必要不时重新检查这种模式。

目的

本研究旨在确定尼日利亚中北部伊洛林儿童肾病综合征的组织病理学特征。

方法

对 2010 年 1 月至 2023 年 12 月期间在伊洛林大学教学医院就诊的所有年龄在 2-14 岁之间具有肾病综合征临床特征的新患者进行了前瞻性研究。所有符合条件的患者均接受了肾活检。

结果

共对 47 例肾病综合征患儿进行了活检，其中男 21 例，女 26 例，男女比例为 1:1.2。受试者年龄范围为 2-14 岁，平均年龄为 7.8±3.6 岁。肾病综合征最常见的组织学类型是微小病变肾病综合征（MCNS），35 例（74.5%）患儿发生 MCNS，其次是膜增生性肾小球肾炎（MPGN）5 例（10.6%）和局灶节段性肾小球硬化症（FSGS）2 例（4.3%）。在 35 例 MCNS 患者中，31 例（88.6%）对类固醇敏感，4 例（11.4%）对类固醇耐药。