Kadiiska M, Stoytchev T, Serbinova E
Arch Toxicol. 1985 Jan;56(3):167-9. doi: 10.1007/BF00333421.
The effect of Co(NO3)2, CdSO4, NiSO4, ZnSO4, and HgCl2 (given repeatedly in subtoxic doses in the drinking water for 30 days) on rat liver monooxygenases was studied in experiments on male Wistar rats. The salts of Co, Cd, and Zn increased the activity of benzphetamine-N-demethylase, the content of cytochrome P-450 and microsomal heme. The data suggest that these salts exert an enzyme-inducing effect on the hepatic monooxygenases. The same metal salts (Co, Cd, and Zn) increased the activity of delta-aminolevulinic acid (ALA) synthetase and decreased that of heme oxygenase. The increased cytochrome P-450 content is probably due to the increased synthesis and the decreased breakdown of this hemoprotein. HgCl2 and NiSO4 did not exert an enzyme-inducing action. The lack of change in the activity of NADPH-cytochrome c reductase and cytochrome b5 (except for ZnSO4) suggests that these components of the electron transport chain are not likely to be involved in the enzyme-inducing action of the heavy metal salts.
在雄性Wistar大鼠实验中，研究了硝酸钴（Co(NO3)2）、硫酸镉（CdSO4）、硫酸镍（NiSO4）、硫酸锌（ZnSO4）和氯化汞（HgCl2）（以亚毒性剂量反复添加到饮用水中30天）对大鼠肝脏单加氧酶的影响。钴、镉和锌的盐类增加了苄非他明-N-脱甲基酶的活性、细胞色素P-450和微粒体血红素的含量。数据表明，这些盐类对肝脏单加氧酶具有酶诱导作用。同样的金属盐（钴、镉和锌）增加了δ-氨基乙酰丙酸（ALA）合成酶的活性，并降低了血红素加氧酶的活性。细胞色素P-450含量的增加可能是由于这种血红蛋白的合成增加和分解减少。氯化汞和硫酸镍没有发挥酶诱导作用。NADPH-细胞色素c还原酶和细胞色素b5活性没有变化（硫酸锌除外），这表明电子传递链的这些组分不太可能参与重金属盐的酶诱导作用。
