采用 2 分钟行军试验与 6 分钟步行试验比较新的心血管耐力测试在健康志愿者中的应用：一项交叉随机对照试验。
A comparison of new cardiovascular endurance test using the 2-minute marching test vs. 6-minute walk test in healthy volunteers: A crossover randomized controlled trial.
机构信息
Rehabilitation Center, Bangkok Hospital Headquarters, Bangkok Dusit Medical Services, Bangkok, Thailand.
Department of Outpatient, Bangbo Hospital, Samutprakarn, Thailand.
出版信息
PLoS One. 2024 Aug 28;19(8):e0307650. doi: 10.1371/journal.pone.0307650. eCollection 2024.
TRIAL DESIGN
This was a 2×2 randomized crossover control trial.
OBJECTIVE
To compare the cardiovascular endurance of healthy volunteers using a 2-minute marching test (2MMT) and a 6-minute walk test (6MWT).
METHODS
This study included 254 participants of both sexes, aged 20-50 years, with a height and body mass index (BMI) of ≥150 cm and ≤25 kg/m2, respectively. Participants were hospital staff who could perform activities independently and had normal annual chest radiographs and electrocardiograms. A group-randomized design was used to assign participants to Sequence 1 (AB) or 2 (BA). The tests were conducted over 2 consecutive days, with a 1-day washout period. On day 1, the participants randomly underwent either a 6MWT or 2MMT in a single-anonymized setup, and on day 2, the tests were performed in reverse order. We analyzed maximal oxygen consumption (VO2max) as the primary outcome and heart rate (HR), respiratory rate (RR), blood pressure (BP), oxygen saturation, dyspnea, and leg fatigue as secondary outcomes.
RESULTS
Data were collected from 127 participants, categorized into two groups for different testing sequences. The first (AB) and second groups had 63 and 64 participants, respectively. The estimated VO2max was equivalent between both groups. The 2MMT and 6MWT estimated VO2max with a mean of 41.00 ± 3.95 mL/kg/min and 40.65 ± 3.98 mL/kg/min, respectively. The mean difference was -0.35 mL/kg/min (95% confidence interval: -1.09 to 0.38; p <0.001), and no treatment and carryover effect were observed. No significant changes were observed in HR, RR, and systolic BP (p = 0.295, p = 0.361 and p = 0.389, respectively). However, significant changes were found in the ratings of perceived exertion (p <0.001) and leg fatigue scale (p <0.001).
CONCLUSION
The 2MMT is practical, simple, and equivalent to the 6MWT in estimating VO2max.
TRIAL REGISTRATION
TCTR20220528004 https://www.thaiclinicaltrials.org.
研究设计
这是一项 2×2 随机交叉对照试验。
目的
比较使用 2 分钟行军测试（2MMT）和 6 分钟步行测试（6MWT）评估健康志愿者心血管耐力的效果。
方法
本研究纳入了 254 名年龄在 20-50 岁、身高和体重指数（BMI）分别≥150cm 和≤25kg/m2 的男女参与者。这些参与者均为能够独立活动且年度胸部 X 光和心电图正常的医院工作人员。采用分组随机设计将参与者分配至序列 1（AB）或序列 2（BA）。在连续两天内进行测试，期间有 1 天洗脱期。第 1 天，参与者在单次匿名设置下随机接受 6MWT 或 2MMT 测试，第 2 天则相反顺序进行测试。我们将最大摄氧量（VO2max）作为主要结局指标，将心率（HR）、呼吸频率（RR）、血压（BP）、血氧饱和度、呼吸困难和腿部疲劳作为次要结局指标进行分析。
结果
共纳入 127 名参与者，根据不同的测试顺序分为两组。第 1 组（AB）和第 2 组分别有 63 名和 64 名参与者。两组的估计 VO2max 无显著差异。2MMT 和 6MWT 估计的 VO2max 平均值分别为 41.00±3.95mL/kg/min 和 40.65±3.98mL/kg/min。平均差值为-0.35mL/kg/min（95%置信区间：-1.09 至 0.38；p<0.001），未观察到治疗和交叉效应。HR、RR 和收缩压无显著变化（p=0.295、p=0.361 和 p=0.389）。然而，在感知用力评分（p<0.001）和腿部疲劳量表（p<0.001）上观察到显著变化。
结论
2MMT 实用、简单，与 6MWT 相比，在估计 VO2max 方面具有等效性。
试验注册
TCTR20220528004，网址：https://www.thaiclinicaltrials.org。
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