Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice 41-800, Poland.
Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice 41-800, Poland.
Mult Scler Relat Disord. 2024 Oct;90:105800. doi: 10.1016/j.msard.2024.105800. Epub 2024 Aug 14.
Multiple sclerosis (MS) is a chronic CNS autoimmune disease characterized by demyelination and neurodegeneration. Chemokines regulate leukocyte migration and inflammation in MS. In the present study, we evaluated selected chemokine levels in the cerebrospinal fluid of patients with multiple sclerosis diagnosed de novo compared to healthy controls.
We measured EOTAXIN, IP-10, MCP-1, MIP-1a, MIP-1b and RANTES in the cerebrospinal fluid of 118 patients with de novo RRMS and 112 controls, analyzing correlations with time from symptom onset to diagnosis and changes in MRI.
Higher levels of EOTAXIN, IP-10, MIP-1B and RANTES, and lower MCP-1 were observed in MS patients compared to controls. MIP-1A did not show statistical significance. EOTAXIN and IP-10 concentrations increased with time. RANTES concentration correlated positively with T2 changes in MRI of the cervical spine, and EOTAXIN concentration correlated negatively with gadolinium (Gd+) changes in the cervical spine. There was no correlation with changes in the thoracic spine or brain.
Chemokines play a significant role in the early phase of MS by influencing inflammatory activity. They may represent potential therapeutic targets for the treatment of this disease.
多发性硬化症（MS）是一种慢性中枢神经系统自身免疫性疾病，其特征是脱髓鞘和神经退行性变。趋化因子调节 MS 中的白细胞迁移和炎症。在本研究中，我们评估了新诊断的多发性硬化症患者脑脊液中选定趋化因子的水平，并与健康对照组进行了比较。
我们测量了 118 例新诊断的 RRMS 患者和 112 例对照组的脑脊液中的 EOTAXIN、IP-10、MCP-1、MIP-1a、MIP-1b 和 RANTES，分析了与从症状发作到诊断的时间以及 MRI 变化的相关性。
与对照组相比，MS 患者的 EOTAXIN、IP-10、MIP-1B 和 RANTES 水平较高，MCP-1 水平较低。MIP-1A 没有统计学意义。EOTAXIN 和 IP-10 浓度随时间增加。RANTES 浓度与颈椎 MRI 的 T2 变化呈正相关，EOTAXIN 浓度与颈椎 Gd+变化呈负相关。与胸腰椎或脑的变化无相关性。
趋化因子通过影响炎症活性在 MS 的早期阶段发挥重要作用。它们可能是治疗这种疾病的潜在治疗靶点。
