Servicio de Neumología, Corporació Sanitària Parc Taulí, Parc Taulí, 1, Sabadell, 08208, Barcelona, Spain; Departamento de Medicina, Universitat Autònoma de Barcelona, Plaça Cívica, Bellaterra, 08193, Barcelona, Spain.
Servicio de Alergia, Hospital Universitario La Paz, P.° de La Castellana, 261, Fuencarral-El Pardo, 28046, Madrid, Spain.
Respir Investig. 2024 Nov;62(6):987-994. doi: 10.1016/j.resinv.2024.08.005. Epub 2024 Aug 27.
Refractory chronic cough (RCC) and unexplained chronic cough (UCC) adversely affect patients' quality of life (QoL). This multicenter, non-interventional study evaluates the relationship between cough severity and QoL and other patient-reported outcomes (PROs) in Spanish outpatients.
RCC/UCC patients self-administered a printed survey comprising the cough-severity visual analog scale (VAS), adapted Cough Severity Diary (CSD), and Leicester Cough Questionnaire (LCQ), plus purpose-designed items regarding the physical and everyday-life impact of cough. Patients were stratified into VAS score tertiles. The impact of cough on QoL and other PROs in each tertile, and relationships between LCQ scores and the tertiles, were assessed.
The VAS was completed by 189 patients, and VAS score tertiles were identified as 0-50, 60-70, and 80-100 mm. The only between-tertile difference in demographic or cough characteristics was cough duration. VAS score tertiles were linearly associated with mean LCQ domain and total scores, as well as the proportion of patients with the highest scores on all adapted CSD items, and almost all physical and everyday-life impact items. In multiple linear-regression models, an increase of one tertile in the VAS score was associated with a decrease of 2.23 points in the LCQ total score, indicating poorer cough-related QoL.
As self-assessed in patients with RCC/UCC, cough-severity VAS scores were strongly associated with the impact of cough on QoL and everyday life. Patients with VAS scores of 60-100 mm reported the greatest impact and thus may benefit the most from targeted cough therapies.
难治性慢性咳嗽（RCC）和不明原因的慢性咳嗽（UCC）会降低患者的生活质量（QoL）。本多中心、非干预性研究评估了西班牙门诊患者咳嗽严重程度与 QoL 和其他患者报告结局（PRO）之间的关系。
RCC/UCC 患者自行填写了一份印刷调查问卷，包括咳嗽严重程度视觉模拟量表（VAS）、改编后的咳嗽严重程度日记（CSD）和莱斯特咳嗽问卷（LCQ），以及关于咳嗽对身体和日常生活影响的特定项目。患者被分层为 VAS 评分三分位组。评估了每个三分位组中咳嗽对 QoL 和其他 PRO 的影响，以及 LCQ 评分与三分位组之间的关系。
189 名患者完成了 VAS，确定了 VAS 评分三分位组为 0-50、60-70 和 80-100mm。在人口统计学或咳嗽特征方面，只有咳嗽持续时间在三分位组之间存在差异。VAS 评分三分位组与平均 LCQ 域和总分以及所有适应 CSD 项目和几乎所有身体和日常生活影响项目中得分最高的患者比例呈线性相关。在多元线性回归模型中，VAS 评分增加一个三分位与 LCQ 总分降低 2.23 分相关，表明咳嗽相关 QoL 更差。
在 RCC/UCC 患者中自我评估，咳嗽严重程度 VAS 评分与咳嗽对 QoL 和日常生活的影响密切相关。VAS 评分在 60-100mm 的患者报告影响最大，因此可能最受益于靶向咳嗽治疗。
