Department of Translational Research NTMS, University of Pisa, Italy.
Department of Translational Research NTMS, University of Pisa, Italy.
Free Radic Biol Med. 2024 Nov 1;224:162-167. doi: 10.1016/j.freeradbiomed.2024.08.032. Epub 2024 Aug 27.
Glutathione transferase omega-1-1 (GSTO1-1) is a member of the glutathione transferase superfamily (GSTs) involved in the modulation of cell survival, proliferation and metabolism. Increased levels of GSTO1-1 have been associated with cancer progression and chemoresistance in different types of cancer cells, possibly supported by the post-traslational regulation of some major prosurvival pathways regulated by the enzyme. Our data demonstrate for the first time that GSTO1-1 can be released by cancer cells through the exosomal route and transferred to GSTO1-1 knock-out cells, this resulting in an increased resistance against cisplatin toxicity in recipient cells. The use of the exosomal route to transfer the regulatory competences of GSTO1-1 could be a further element supporting its role in neoplastic progression.
谷胱甘肽 S-转移酶ω-1-1（GSTO1-1）是谷胱甘肽 S-转移酶超家族（GSTs）的成员，参与细胞存活、增殖和代谢的调节。在不同类型的癌细胞中，GSTO1-1 水平的增加与癌症进展和化疗耐药性有关，这可能得到该酶调节的一些主要生存途径的翻译后调控的支持。我们的数据首次表明，GSTO1-1 可以通过细胞外体途径被癌细胞释放，并转移到 GSTO1-1 敲除细胞中，这导致受体细胞对顺铂毒性的抵抗力增加。利用细胞外体途径转移 GSTO1-1 的调节能力可能是支持其在肿瘤进展中作用的另一个因素。
