Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR 999078, China.
Gynaecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Chin J Nat Med. 2024 Aug;22(8):711-723. doi: 10.1016/S1875-5364(24)60581-9.
The pathogenesis of orthopedic diseases is intimately linked to blood stasis, frequently arising from damage to primary and secondary blood channels. This disruption can lead to "blood leaving the meridians" or Qi stagnation, resulting in blood stasis syndrome. Taohong Siwu Decoction (THSWD) is a renowned classical Chinese medicinal formula extensively used to promote blood circulation and mitigate blood stasis. Clinical studies have demonstrated its significant therapeutic effects on various orthopedic conditions, particularly its anti-inflammatory and analgesic properties, as well as its efficacy in preventing deep vein thrombosis post-surgery. Despite these findings, research on THSWD remains fragmented, and its interdisciplinary impact is limited. This review aims to provide a comprehensive evaluation of the efficacy and pharmacological mechanisms of THSWD in treating common orthopedic diseases. Additionally, we employ bibliometric analysis to explore research trends and hotspots related to THSWD. We hope this review will enhance the recognition and application of THSWD in orthopedic treatments and guide future research into its pharmacological mechanisms.
骨科疾病的发病机制与血瘀密切相关，常因气血通道的原发性和继发性损伤而发生。这种紊乱会导致“血离经脉”或气滞，从而形成血瘀证。桃红四物汤（THSWD）是一种著名的经典中药方剂，广泛用于促进血液循环和缓解血瘀。临床研究表明，它对各种骨科疾病具有显著的治疗作用，特别是其抗炎和镇痛作用，以及在术后预防深静脉血栓形成方面的功效。尽管有这些发现，但对 THSWD 的研究仍然零散，其跨学科影响有限。本综述旨在全面评估 THSWD 治疗常见骨科疾病的疗效和药理学机制。此外，我们还采用文献计量分析来探讨与 THSWD 相关的研究趋势和热点。我们希望本综述将提高对 THSWD 在骨科治疗中的认识和应用，并指导对其药理学机制的未来研究。
