Rowbotham Nicola J, Smith Sherie, Jahnke Nikki, Milczanowski Sarah, Elliott Zoe C, Prayle Andrew P, Smyth Alan R
Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK.
Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK.
J Cyst Fibros. 2025 Mar;24(2):359-363. doi: 10.1016/j.jcf.2024.08.004. Epub 2024 Aug 28.
Preventing transmissible infection is a priority in cystic fibrosis (CF) care. This is an update of a systematic review of the evidence for infection prevention and control interventions in CF. Our full protocol can be found on PROSPERO (CRD42018109999). We searched for studies and guidelines which included interventions for infection prevention and control in CF. We included 39 studies and 7 guidelines. Strategies included: cohort or individual segregation, hand hygiene, facemasks, equipment, enhanced adherence or a combination of these. Many studies showed a reduction in transmission with segregation. However, the certainty of evidence (using GRADE) was low or very low. Most guideline recommendations have little evidence to support them, with no updates since our original review. Undertaking RCTs in this area is ethically difficult. Large-scale registry-based studies may be the best pragmatic approach. Benefits of infection control must be balanced against the intrusion in the lives of people with CF.
预防可传播感染是囊性纤维化（CF）护理的首要任务。这是对CF感染预防与控制干预措施证据的系统评价的更新。我们的完整方案可在PROSPERO（CRD42018109999）上找到。我们检索了包括CF感染预防与控制干预措施的研究和指南。我们纳入了39项研究和7项指南。策略包括：队列或个体隔离、手卫生、口罩、设备、强化依从性或这些措施的组合。许多研究表明隔离可减少传播。然而，证据的确定性（使用GRADE）为低或极低。大多数指南建议几乎没有证据支持，自我们最初的综述以来也没有更新。在该领域进行随机对照试验在伦理上具有难度。基于大型登记处的研究可能是最佳的务实方法。感染控制的益处必须与对CF患者生活的干扰相平衡。
