Department of Traumatology and Orthopedics, The First People's Hospital of Qujing, Yunnan, China.
APMIS. 2024 Nov;132(11):760-774. doi: 10.1111/apm.13462. Epub 2024 Aug 28.
HERC5, a vital protein in the HERC family, plays crucial roles in immune response, cancer progression, and antiviral defense. This bioinformatic study comprehensively assessed HERC5's significance across various malignancies by analyzing its gene expression, immune and molecular subtype expressions, target proteins, biological functions, and prognostic and diagnostic values in pan-cancer. We further examined its correlation with clinical features, co-expressed and differentially expressed genes, and prognosis in clinical subgroups, focusing on endometrial cancer (UCEC). Our findings showed that HERC5 RNA is expressed at low levels in most cancers and significantly differs across immune and molecular subtypes. HERC5 accurately predicts cancer and correlates with most cancer prognoses. In UCEC, HERC5 was significantly associated with age, hormonal status, clinical stage, treatment status, and metastasis. Elevated HERC5 expression was linked to worse progression-free interval, disease-specific survival, and overall survival in UCEC, particularly in diverse clinical subgroups. Significant differences in HERC5 expression were also observed in various human cancer cell line validations. In summary, HERC5 may be a critical biomarker for pan-cancer prognosis, progression, and diagnosis, as well as a promising new target for cancer therapy.
HERC5 是 HERC 家族中的一种重要蛋白质，在免疫反应、癌症进展和抗病毒防御中发挥关键作用。本生物信息学研究通过分析 HERC5 在泛癌中的基因表达、免疫和分子亚型表达、靶蛋白、生物学功能以及预后和诊断价值，全面评估了其在各种恶性肿瘤中的意义。我们进一步研究了其与临床特征、共表达和差异表达基因以及临床亚组中预后的相关性，重点关注子宫内膜癌 (UCEC)。研究结果表明，HERC5 RNA 在大多数癌症中的表达水平较低，且在免疫和分子亚型之间存在显著差异。HERC5 可准确预测癌症并与大多数癌症预后相关。在 UCEC 中，HERC5 与年龄、激素状态、临床分期、治疗状态和转移显著相关。在 UCEC 中，HERC5 表达升高与无进展生存期、疾病特异性生存期和总生存期较差相关，尤其是在不同的临床亚组中。在各种人类癌细胞系验证中也观察到 HERC5 表达的显著差异。总之，HERC5 可能是泛癌预后、进展和诊断的重要生物标志物，也是癌症治疗的有前途的新靶点。
