Gimblet Colin J, Kruse Nicholas T, Geasland Katharine, Michelson Jeni, Sun Mingyao, Ten Eyck Patrick, Linkenmeyer Cari, Mandukhail Safur Rehman, Rossman Matthew J, Sambharia Meenakshi, Chonchol Michel, Kurella Tamura Manjula, Seals Douglas, Hoth Karin F, Jalal Diana
Division of Nephrology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 375 Newton Rd, Iowa City, IA 52246, USA.
College of Health Professionals, Central Michigan University, Mount Pleasant, MI 48859, USA.
Antioxidants (Basel). 2024 Aug 14;13(8):983. doi: 10.3390/antiox13080983.
Chronic kidney disease (CKD) increases the risk of cardiovascular disease and cognitive impairment. Curcumin is a polyphenol that improves vascular and cognitive function in older adults; however, its effects on vascular and cognitive function in patients with CKD are unknown. We hypothesized that curcumin supplementation would improve vascular and cognitive function in patients with CKD. Eighty-eight adults diagnosed with stage 3b or 4 CKD (aged 66 ± 8 years, 75% male) participated in a 12-month, randomized, double-blind, placebo-controlled study to test the effects of curcumin (Longvida, 2000 mg/day) on vascular and cognitive function. Our primary outcome was brachial artery flow-mediated dilation (FMD). Our secondary outcomes were nitroglycerin-mediated dilation, carotid-femoral pulse wave velocity (cfPWV), and cognitive function assessed via the NIH Toolbox Cognition Battery. At baseline, the mean estimated glomerular filtration rate was 34.7 ± 10.8, and the median albumin/creatinine ratio was 81.9 (9.7, 417.3). A total of 44% of participants had diabetes. Compared with placebo, 12 months of curcumin did not improve FMD (median change from baseline was -0.7 (-2.1, 1.1) and -0.1 (-1.5, 1.5) for curcumin and placebo, respectively, with = 0.69). Similarly, there were no changes in nitroglycerin-mediated dilation, cfPWV, or cognitive outcomes. These results do not support chronic curcumin supplementation to improve vascular and cognitive function in patients with CKD.
慢性肾脏病（CKD）会增加心血管疾病和认知障碍的风险。姜黄素是一种多酚类物质，可改善老年人的血管和认知功能；然而，其对CKD患者血管和认知功能的影响尚不清楚。我们假设补充姜黄素会改善CKD患者的血管和认知功能。88名被诊断为3b期或4期CKD的成年人（年龄66±8岁，75%为男性）参与了一项为期12个月的随机、双盲、安慰剂对照研究，以测试姜黄素（Longvida，2000毫克/天）对血管和认知功能的影响。我们的主要结局是肱动脉血流介导的血管舒张（FMD）。次要结局包括硝酸甘油介导的血管舒张、颈股脉搏波速度（cfPWV），以及通过美国国立卫生研究院工具箱认知电池评估的认知功能。基线时，平均估计肾小球滤过率为34.7±10.8，白蛋白/肌酐比值中位数为81.9（9.7，417.3）。共有44%的参与者患有糖尿病。与安慰剂相比，服用12个月姜黄素并未改善FMD（姜黄素组和安慰剂组从基线的中位数变化分别为-0.7（-2.1，1.1）和-0.1（-1.5，1.5），P = 0.69）。同样，硝酸甘油介导的血管舒张、cfPWV或认知结局也没有变化。这些结果不支持长期补充姜黄素以改善CKD患者的血管和认知功能。
